Blood-based Diagnostics of Traumatic Brain Injuries

Overview

Journal Expert Rev Mol Diagn

Specialty Molecular Biology

Date 2010 Dec 22

PMID 21171922

Citations 67

Authors

Stefania Mondello

Uwe Muller

Andreas Jeromin

Jackson Streeter

Ronald L Hayes

Kevin K W Wang

Affiliations

Soon will be listed here.

Abstract

Traumatic brain injury is a major health and socioeconomic problem that affects all societies. However, traditional approaches to the classification of clinical severity are the subject of debate and are being supplemented with structural and functional neuroimaging, as the need for biomarkers that reflect elements of the pathogenetic process is widely recognized. Basic science research and developments in the field of proteomics have greatly advanced our knowledge of the mechanisms involved in damage and have led to the discovery and rapid detection of new biomarkers that were not available previously. However, translating this research for patients' benefits remains a challenge. In this article, we summarize new developments, current knowledge and controversies, focusing on the potential role of these biomarkers as diagnostic, prognostic and monitoring tools of brain-injured patients.

Citing Articles

Change in Enlarged Perivascular Spaces over Time and Associations with Outcomes After Traumatic Brain Injury.

Walter A, Savalia K, Yoon J, Morrison J, Schneider A, Diaz-Arrastia R Neurotrauma Rep. 2024; 5(1):738-748.

PMID: 39144451 PMC: 11319858. DOI: 10.1089/neur.2024.0026.

Neuroforensomics: metabolites as valuable biomarkers in cerebrospinal fluid of lethal traumatic brain injuries.

Bohnert S, Reinert C, Trella S, Cattaneo A, Preiss U, Bohnert M Sci Rep. 2024; 14(1):13651.

PMID: 38871842 PMC: 11176198. DOI: 10.1038/s41598-024-64312-0.

The Association between Glymphatic System and Perivascular Macrophages in Brain Waste Clearance.

Kaur J, Boyd E, Ding G, Zhang L, Luo H, Li Q Diagnostics (Basel). 2024; 14(7).

PMID: 38611644 PMC: 11011895. DOI: 10.3390/diagnostics14070731.

Advances in neuroproteomics for neurotrauma: unraveling insights for personalized medicine and future prospects.

Kobeissy F, Goli M, Yadikar H, Shakkour Z, Kurup M, Haidar M Front Neurol. 2023; 14:1288740.

PMID: 38073638 PMC: 10703396. DOI: 10.3389/fneur.2023.1288740.

Imaging glymphatic response to glioblastoma.

Kaur J, Ding G, Zhang L, Lu Y, Luo H, Li L Cancer Imaging. 2023; 23(1):107.

PMID: 37904254 PMC: 10614361. DOI: 10.1186/s40644-023-00628-w.

References

Kochanek A, Kline A, Gao W, Chadha M, Lai Y, Clark R . Gel-based hippocampal proteomic analysis 2 weeks following traumatic brain injury to immature rats using controlled cortical impact. Dev Neurosci. 2006; 28(4-5):410-9. PMC: 2721469. DOI: 10.1159/000094167. View

Davis F, Higson S . Label-free immunochemistry approach to detect and identity antibiotics in milk. Pediatr Res. 2010; 67(5):476-80. DOI: 10.1203/PDR.0b013e3181d61c0c. View

Pike B, Flint J, Dave J, Lu X, Wang K, Tortella F . Accumulation of calpain and caspase-3 proteolytic fragments of brain-derived alphaII-spectrin in cerebral spinal fluid after middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab. 2003; 24(1):98-106. DOI: 10.1097/01.WCB.0000098520.11962.37. View

Siman R, Toraskar N, Dang A, McNeil E, McGarvey M, Plaum J . A panel of neuron-enriched proteins as markers for traumatic brain injury in humans. J Neurotrauma. 2009; 26(11):1867-77. PMC: 2822802. DOI: 10.1089/neu.2009.0882. View

Wu M, Long S, Frutos A, Eichelberger M, Li M, Fang Y . Interrogation of phosphor-specific interaction on a high-throughput label-free optical biosensor system-Epic system. J Recept Signal Transduct Res. 2009; 29(3-4):202-10. DOI: 10.1080/10799890903068474. View

Kokko L, Kokko T, Lovgren T, Soukka T . Particulate and soluble Eu(III)-chelates as donor labels in homogeneous fluorescence resonance energy transfer based immunoassay. Anal Chim Acta. 2007; 606(1):72-9. DOI: 10.1016/j.aca.2007.10.038. View

Ingebrigtsen T, Romner B . Biochemical serum markers of traumatic brain injury. J Trauma. 2002; 52(4):798-808. DOI: 10.1097/00005373-200204000-00038. View

Zemlan F, Rosenberg W, Luebbe P, Campbell T, Dean G, Weiner N . Quantification of axonal damage in traumatic brain injury: affinity purification and characterization of cerebrospinal fluid tau proteins. J Neurochem. 1999; 72(2):741-50. DOI: 10.1046/j.1471-4159.1999.0720741.x. View

Lumpkins K, Bochicchio G, Keledjian K, Simard J, McCunn M, Scalea T . Glial fibrillary acidic protein is highly correlated with brain injury. J Trauma. 2008; 65(4):778-82. DOI: 10.1097/TA.0b013e318185db2d. View

10.

Barth J, Macciocchi S, Giordani B, Rimel R, Jane J, Boll T . Neuropsychological sequelae of minor head injury. Neurosurgery. 1983; 13(5):529-33. DOI: 10.1227/00006123-198311000-00008. View

11.

Romner B, Ingebrigtsen T, Kongstad P, Borgesen S . Traumatic brain damage: serum S-100 protein measurements related to neuroradiological findings. J Neurotrauma. 2000; 17(8):641-7. DOI: 10.1089/089771500415391. View

12.

Yang X, Yang S, Wang J, Zhang X, Wang C, Hong G . Expressive proteomics profile changes of injured human brain cortex due to acute brain trauma. Brain Inj. 2009; 23(10):830-40. DOI: 10.1080/02699050903196670. View

13.

Narayan R, Michel M, Ansell B, Baethmann A, Biegon A, Bracken M . Clinical trials in head injury. J Neurotrauma. 2002; 19(5):503-57. PMC: 1462953. DOI: 10.1089/089771502753754037. View

14.

Malmqvist . Epitope Mapping by Label-Free Biomolecular Interaction Analysis. Methods. 1996; 9(3):525-32. DOI: 10.1006/meth.1996.0060. View

15.

Siman R, McIntosh T, Soltesz K, Chen Z, Neumar R, Roberts V . Proteins released from degenerating neurons are surrogate markers for acute brain damage. Neurobiol Dis. 2004; 16(2):311-20. DOI: 10.1016/j.nbd.2004.03.016. View

16.

Raabe A, Grolms C, Keller M, Dohnert J, Sorge O, Seifert V . Correlation of computed tomography findings and serum brain damage markers following severe head injury. Acta Neurochir (Wien). 1998; 140(8):787-91; discussion 791-2. DOI: 10.1007/s007010050180. View

17.

Mettler Jr F, Bhargavan M, Faulkner K, Gilley D, Gray J, Ibbott G . Radiologic and nuclear medicine studies in the United States and worldwide: frequency, radiation dose, and comparison with other radiation sources--1950-2007. Radiology. 2009; 253(2):520-31. DOI: 10.1148/radiol.2532082010. View

18.

Cole T . Global road safety crisis remedy sought: 1.2 million killed, 50 million injured annually. JAMA. 2004; 291(21):2531-2. DOI: 10.1001/jama.291.21.2531. View

19.

Raabe A, Grolms C, Seifert V . Serum markers of brain damage and outcome prediction in patients after severe head injury. Br J Neurosurg. 1999; 13(1):56-9. DOI: 10.1080/02688699944195. View

20.

Sanchez-Martinez M, Aguilar-Caballos M, Gomez-Hens A . Homogeneous immunoassay for soy protein determination in food samples using gold nanoparticles as labels and light scattering detection. Anal Chim Acta. 2009; 636(1):58-62. DOI: 10.1016/j.aca.2009.01.043. View