Short Term Dietary Fish Oil Supplementation Improves Motor Deficiencies Related to Reserpine-induced Parkinsonism in Rats

Overview

Journal Lipids

Specialty Biochemistry

Date 2010 Dec 17

PMID 21161603

Citations 5

Authors

Raquel Cristine Silva Barcelos

Dalila Moter Benvegnu

Nardeli Boufleur

Camila Pase

Angelica Martelli Teixeira

Patricia Reckziegel

Tatiana Emanuelli

Joao Batista T da Rocha

Marilise Escobar Burger

Affiliations

Soon will be listed here.

Abstract

Fish oil (FO) supplementation could cause an increase in the concentration of plasmatic free fatty acids and, consequently, could compete with pro-inflammatory arachidonic acid (ARA) derived from brain biomembranes metabolism in the cerebrospinal fluid. Essential fatty acids (EFA) (n-3) have been reported by their antioxidant and neuroprotective properties, and therefore the influence of the FO supplementation on the reserpine-induced motor disorders was studied. Wistar rats were orally treated with FO solution for 5 days, and co-treated with reserpine (R; 1 mg/kg/mL) or its vehicle for 3 days (every other day). Reserpine-induced orofacial dyskinesia and catalepsy (P < 0.05) were prevented by FO (P < 0.05). Biochemical evaluations showed that reserpine treatment increased the lipid peroxidation in the cortex and striatum (P < 0.05), while the FO supplementation prevented this oxidative effect in both brain regions (P < 0.05). Our results showed the protective role of FO in the brain lipid membranes, reinforcing the beneficial effect of n-3 fatty acids in the prevention of degenerative and motor disorders.

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