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Alkaloids from Stems of Esenbeckia Leiocarpa Engl. (Rutaceae) As Potential Treatment for Alzheimer Disease

Overview
Journal Molecules
Publisher MDPI
Specialty Biology
Date 2010 Dec 17
PMID 21160449
Citations 18
Authors
Elaine Monteiro Cardoso-Lopes
James Andreas Maier
Marcelo Rogerio da Silva
Luis Octavio Regasini
Simone Yasue Simote
Norberto Peporine Lopes
Jose Rubens Pirani
Vanderlan da Silva Bolzani
Maria Claudia Marx Young
Affiliations
Soon will be listed here.
Abstract

Esenbeckia leiocarpa Engl. (Rutaceae), popularly known as guarantã, goiabeira, is a native tree from Brazil. Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity. The alkaloid leptomerine showed the highest activity (IC₅₀ = 2.5 mM), similar to that of the reference compound galanthamine (IC₅₀ = 1.7 mM). The results showed for the first time the presence of alkaloids leptomerine and skimmianine in E. leiocarpa (Engl.) with potent anticholinesterasic activity.

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