Biologically Active Quinoline and Quinazoline Alkaloids Part II

Overview

Journal Med Res Rev

Publisher Wiley

Specialties General Medicine
Pharmacology

Date 2018 Feb 28

PMID 29485730

Citations 37

Authors

Xiao-Fei Shang

Susan L Morris-Natschke

Guan-Zhou Yang

Ying-Qian Liu

Xiao Guo

Xiao-Shan Xu

Masuo Goto

Jun-Cai Li

Ji-Yu Zhang

Kuo-Hsiung Lee

Affiliations

Soon will be listed here.

Abstract

To follow-up on our prior Part I review, this Part II review summarizes and provides updated literature on novel quinoline and quinazoline alkaloids isolated during the period of 2009-2016, together with the biological activity and the mechanisms of action of these classes of natural products. Over 200 molecules with a broad range of biological activities, including antitumor, antiparasitic and insecticidal, antibacterial and antifungal, cardioprotective, antiviral, anti-inflammatory, hepatoprotective, antioxidant, anti-asthma, antitussive, and other activities, are discussed. This survey should provide new clues or possibilities for the discovery of new and better drugs from the original naturally occurring quinoline and quinazoline alkaloids.

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