» Articles » PMID: 21146993

Assembly of Infectious Hepatitis C Virus Particles

Overview
Date 2010 Dec 15
PMID 21146993
Citations 218
Authors
Affiliations
Soon will be listed here.
Abstract

A hallmark of the hepatitis C virus (HCV) replication cycle is its tight link with host cell lipid synthesis. This is best illustrated by the peculiar pathway used for the assembly of infectious HCV particles. Research in the past few years has shown that formation of HC-virions is closely connected to lipid droplets that could serve as an assembly platform. Moreover, HCV particle production appears to be strictly linked to very-low-density lipoproteins. In this review, we focus on new insights into the molecular aspects of the architecture and assembly of this unique type of virus particle.

Citing Articles

Hijacking host extracellular vesicle machinery by hepatotropic viruses: current understandings and future prospects.

Chu Y, Chen M, Yeh C, Lai M J Biomed Sci. 2024; 31(1):97.

PMID: 39369194 PMC: 11453063. DOI: 10.1186/s12929-024-01063-0.


Lipoprotein Lipidomics as a Frontier in Non-Alcoholic Fatty Liver Disease Biomarker Discovery.

Herrera-Marcos L, Arbones-Mainar J, Osada J Int J Mol Sci. 2024; 25(15).

PMID: 39125855 PMC: 11311740. DOI: 10.3390/ijms25158285.


After the Storm: Persistent Molecular Alterations Following HCV Cure.

Seurre C, Roca Suarez A, Testoni B, Zoulim F, Grigorov B Int J Mol Sci. 2024; 25(13).

PMID: 39000179 PMC: 11241208. DOI: 10.3390/ijms25137073.


Lipid Profile and Cardiovascular Risk Modification after Hepatitis C Virus Eradication.

Pascual-Oliver A, Casas-Deza D, Yague-Caballero C, Arbones-Mainar J, Bernal-Monterde V Pathogens. 2024; 13(4).

PMID: 38668233 PMC: 11054742. DOI: 10.3390/pathogens13040278.


The Dynamic Landscape of Capsid Proteins and Viral RNA Interactions in Flavivirus Genome Packaging and Virus Assembly.

Jablunovsky A, Jose J Pathogens. 2024; 13(2).

PMID: 38392858 PMC: 10893219. DOI: 10.3390/pathogens13020120.