Pain and the Brain: Specificity and Plasticity of the Brain in Clinical Chronic Pain

Overview

Journal Pain

Specialties Neurology
Psychiatry

Date 2010 Dec 15

PMID 21146929

Citations 282

Authors

Vania A Apkarian

Javeria A Hashmi

Marwan N Baliki

Affiliations

Soon will be listed here.

Citing Articles

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References

May A . Chronic pain may change the structure of the brain. Pain. 2008; 137(1):7-15. DOI: 10.1016/j.pain.2008.02.034. View

Kurth F, Zilles K, Fox P, Laird A, Eickhoff S . A link between the systems: functional differentiation and integration within the human insula revealed by meta-analysis. Brain Struct Funct. 2010; 214(5-6):519-34. PMC: 4801482. DOI: 10.1007/s00429-010-0255-z. View

Hofbauer R, Rainville P, Duncan G, Bushnell M . Cortical representation of the sensory dimension of pain. J Neurophysiol. 2001; 86(1):402-11. DOI: 10.1152/jn.2001.86.1.402. View

Neugebauer V, Li W, Bird G, Han J . The amygdala and persistent pain. Neuroscientist. 2004; 10(3):221-34. DOI: 10.1177/1073858403261077. View

Napadow V, LaCount L, Park K, As-Sanie S, Clauw D, Harris R . Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity. Arthritis Rheum. 2010; 62(8):2545-55. PMC: 2921024. DOI: 10.1002/art.27497. View

Zubieta J, Smith Y, Bueller J, Xu Y, Kilbourn M, Jewett D . Regional mu opioid receptor regulation of sensory and affective dimensions of pain. Science. 2001; 293(5528):311-5. DOI: 10.1126/science.1060952. View

Ploghaus A, Tracey I, Gati J, Clare S, Menon R, Matthews P . Dissociating pain from its anticipation in the human brain. Science. 1999; 284(5422):1979-81. DOI: 10.1126/science.284.5422.1979. View

Coghill R, Sang C, Maisog J, Iadarola M . Pain intensity processing within the human brain: a bilateral, distributed mechanism. J Neurophysiol. 1999; 82(4):1934-43. DOI: 10.1152/jn.1999.82.4.1934. View

Kwan C, Diamant N, Pope G, Mikula K, Mikulis D, Davis K . Abnormal forebrain activity in functional bowel disorder patients with chronic pain. Neurology. 2005; 65(8):1268-77. DOI: 10.1212/01.wnl.0000180971.95473.cc. View

10.

Meyer R, Campbell J . Myelinated nociceptive afferents account for the hyperalgesia that follows a burn to the hand. Science. 1981; 213(4515):1527-9. DOI: 10.1126/science.7280675. View

11.

Lang S, Kroll A, Lipinski S, Wessa M, Ridder S, Christmann C . Context conditioning and extinction in humans: differential contribution of the hippocampus, amygdala and prefrontal cortex. Eur J Neurosci. 2009; 29(4):823-32. PMC: 2695154. DOI: 10.1111/j.1460-9568.2009.06624.x. View

12.

Rodriguez-Raecke R, Niemeier A, Ihle K, Ruether W, May A . Brain gray matter decrease in chronic pain is the consequence and not the cause of pain. J Neurosci. 2009; 29(44):13746-50. PMC: 6666725. DOI: 10.1523/JNEUROSCI.3687-09.2009. View

13.

Davis K, Pope G, Chen J, Kwan C, Crawley A, Diamant N . Cortical thinning in IBS: implications for homeostatic, attention, and pain processing. Neurology. 2007; 70(2):153-4. DOI: 10.1212/01.wnl.0000295509.30630.10. View

14.

Cauda F, DAgata F, Sacco K, Duca S, Cocito D, Paolasso I . Altered resting state attentional networks in diabetic neuropathic pain. J Neurol Neurosurg Psychiatry. 2009; 81(7):806-11. DOI: 10.1136/jnnp.2009.188631. View

15.

Starr C, Sawaki L, Wittenberg G, Burdette J, Oshiro Y, Quevedo A . Roles of the insular cortex in the modulation of pain: insights from brain lesions. J Neurosci. 2009; 29(9):2684-94. PMC: 2748680. DOI: 10.1523/JNEUROSCI.5173-08.2009. View

16.

Borsook D, Becerra L . Phenotyping central nervous system circuitry in chronic pain using functional MRI: considerations and potential implications in the clinic. Curr Pain Headache Rep. 2007; 11(3):201-7. DOI: 10.1007/s11916-007-0191-7. View

17.

Davis K, Pope G, Crawley A, Mikulis D . Neural correlates of prickle sensation: a percept-related fMRI study. Nat Neurosci. 2002; 5(11):1121-2. DOI: 10.1038/nn955. View

18.

Loggia M, Mogil J, Bushnell M . Empathy hurts: compassion for another increases both sensory and affective components of pain perception. Pain. 2007; 136(1-2):168-76. DOI: 10.1016/j.pain.2007.07.017. View

19.

Hsu M, Harris R, Sundgren P, Welsh R, Fernandes C, Clauw D . No consistent difference in gray matter volume between individuals with fibromyalgia and age-matched healthy subjects when controlling for affective disorder. Pain. 2009; 143(3):262-267. PMC: 2719961. DOI: 10.1016/j.pain.2009.03.017. View

20.

Davis K, Taylor K, Hutchison W, Dostrovsky J, McAndrews M, Richter E . Human anterior cingulate cortex neurons encode cognitive and emotional demands. J Neurosci. 2005; 25(37):8402-6. PMC: 6725669. DOI: 10.1523/JNEUROSCI.2315-05.2005. View