Angiogenic Activity of Dentin Matrix Components

Overview

Journal J Endod

Publisher Elsevier

Specialty Dentistry

Date 2010 Dec 15

PMID 21146071

Citations 28

Authors

Rong Zhang

Paul R Cooper

Gay Smith

Jacques E Nor

Anthony J Smith

Affiliations

Soon will be listed here.

Abstract

Unlabelled: Angiogenesis is key to both the development and regeneration of the dentin-pulp complex.

Objective: We hypothesized that proangiogenic signaling molecules sequestered in dentin matrix can be solubilised to induce angiogenic events.

Methods: Matrix components were extracted from powdered sound human dentin with EDTA and their dose-dependent (0.0001-5 mg/mL) effects examined in endothelial cells in an in vitro angiogenic tube formation assay, proliferation assay, and transcriptional regulation of the VEGF and VEGF-R2 genes.

Results: Lower concentrations of dentin matrix components were found to show proangiogenic activity, whereas higher concentrations suppressed angiogenic activity.

Conclusion: This study highlights that the release of dentin matrix components after dental injury can contribute to the angiogenic events that support pulp regeneration.

Citing Articles

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Investigation of genetic polymorphisms in genes encoding growth factors and dental pulp calcification in orthodontic patients.

Meyfarth S, Ramirez I, Silva-Sousa A, Proff P, Gabardo M, Sousa-Neto M J Oral Biol Craniofac Res. 2024; 14(6):712-719.

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Effect of Calcium Silicate-Based Intracanal Medicament and Calcium Hydroxide on Growth Factor TGF-β1 Release from Root Canal Dentine.

Bilvinaite G, Drukteinis S, Simoliunas E, Widbiller M, Sakirzanovas S J Funct Biomater. 2024; 15(6).

PMID: 38921513 PMC: 11205060. DOI: 10.3390/jfb15060139.

Biopolymers and Their Application in Bioprinting Processes for Dental Tissue Engineering.

Kim S, Hwangbo H, Chae S, Lee H Pharmaceutics. 2023; 15(8).

PMID: 37631331 PMC: 10457894. DOI: 10.3390/pharmaceutics15082118.

Biodegradation of an injectable treated dentin matrix hydrogel as a novel pulp capping agent for dentin regeneration.

Holiel A, Mustafa H, Sedek E BMC Oral Health. 2023; 23(1):126.

PMID: 36841767 PMC: 9960635. DOI: 10.1186/s12903-023-02831-4.