Boron Neutron Capture Therapy (BNCT) for the Treatment of Liver Metastases: Biodistribution Studies of Boron Compounds in an Experimental Model

Overview

Journal Radiat Environ Biophys

Specialties Biophysics
Environmental Health
Oncology
Radiology

Date 2010 Dec 7

PMID 21132507

Citations 17

Authors

Marcela A Garabalino

Andrea Monti Hughes

Ana J Molinari

Elisa M Heber

Emiliano C C Pozzi

Jorge E Cardoso

Lucas L Colombo

Susana Nievas

David W Nigg

Romina F Aromando

Maria E Itoiz

Veronica A Trivillin

Amanda E Schwint

Affiliations

Soon will be listed here.

Abstract

We previously demonstrated the therapeutic efficacy of different boron neutron capture therapy (BNCT) protocols in an experimental model of oral cancer. BNCT is based on the selective accumulation of (10)B carriers in a tumor followed by neutron irradiation. Within the context of exploring the potential therapeutic efficacy of BNCT for the treatment of liver metastases, the aim of the present study was to perform boron biodistribution studies in an experimental model of liver metastases in rats. Different boron compounds and administration conditions were assayed to determine which administration protocols would potentially be therapeutically useful in in vivo BNCT studies at the RA-3 nuclear reactor. A total of 70 BDIX rats were inoculated in the liver with syngeneic colon cancer cells DHD/K12/TRb to induce the development of subcapsular tumor nodules. Fourteen days post-inoculation, the animals were used for biodistribution studies. We evaluated a total of 11 administration protocols for the boron compounds boronophenylalanine (BPA) and GB-10 (Na(2)(10)B(10)H(10)), alone or combined at different dose levels and employing different administration routes. Tumor, normal tissue, and blood samples were processed for boron measurement by atomic emission spectroscopy. Six protocols proved potentially useful for BNCT studies in terms of absolute boron concentration in tumor and preferential uptake of boron by tumor tissue. Boron concentration values in tumor and normal tissues in the liver metastases model show it would be feasible to reach therapeutic BNCT doses in tumor without exceeding radiotolerance in normal tissue at the thermal neutron facility at RA-3.

Citing Articles

Nucleoside Scaffolds and Carborane Clusters for Boron Neutron Capture Therapy: Developments and Future Perspective.

Khalil A, Adam M Curr Med Chem. 2023; 31(35):5739-5754.

PMID: 37818562 DOI: 10.2174/0109298673245020230929152030.

Enhanced Resolution of Neutron Autoradiography with UV-C Sensitization to Study Boron Microdistribution in Animal Models.

Portu A, Espain M, Thorp S, Trivillin V, Curotto P, Monti Hughes A Life (Basel). 2023; 13(7).

PMID: 37511953 PMC: 10381447. DOI: 10.3390/life13071578.

Therapeutic Efficacy, Radiotoxicity and Abscopal Effect of BNCT at the RA-3 Nuclear Reactor Employing Oligo-Fucoidan and Glutamine as Adjuvants in an Ectopic Colon Cancer Model in Rats.

Frydryk Benitez D, Palmieri M, Langle Y, Monti Hughes A, Pozzi E, Thorp S Life (Basel). 2023; 13(7).

PMID: 37511913 PMC: 10381875. DOI: 10.3390/life13071538.

Measurement of an evaporation coefficient in tissue sections as a correction factor for B determination.

Espector N, Portu A, Espain M, Leyva G, Saint Martin G Histochem Cell Biol. 2023; 160(1):3-10.

PMID: 37126141 DOI: 10.1007/s00418-023-02200-w.

Boron Neutron Capture Therapy (BNCT) Mediated by Maleimide-Functionalized -Dodecaborate Albumin Conjugates (MID:BSA) for Oral Cancer: Biodistribution Studies and BNCT in the Hamster Cheek Pouch Oral Cancer Model.

Monti Hughes A, Goldfinger J, Palmieri M, Ramos P, Santa Cruz I, De Leo L Life (Basel). 2022; 12(7).

PMID: 35888170 PMC: 9323568. DOI: 10.3390/life12071082.

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