How to Study Boron Biodistribution in Liver Metastases from Colorectal Cancer

Overview

Journal J Chemother

Specialties Infectious Diseases
Oncology

Date 2005 Jan 29

PMID 15675469

Citations 3

Authors

L Roveda

U Prati

J Bakeine

F Trotta

P Marotta

P Valsecchi

A Zonta

R Nano

A Facoetti

P Chiari

S Barni

T Pinelli

S Altieri

A Braghieri

P Bruschi

F Fossati

P Pedroni

Affiliations

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Abstract

The purpose of this study was to evaluate boron distribution for a safe and effective BNCT (Boron Neutron Capture Therapy) of liver metastases. Samples both from healthy and tumour liver parenchyma were analysed, after i.v. boron administration, by: alpha particles counting under neutron irradiation; morphological analysis by standard haematoxylin-eosin staining; neutron autoradiography. Our method was unaffected by the cytological heterogeneity inside tumour nodules; it demonstrated selective boron distribution in tumour tissue and predicted estimated mean therapeutic doses in tumour and safety doses in healthy tissue. The time interval for efficient BNCT was 2 to 4 hours after i.v. boron administration.

Citing Articles

Fluorescent Neutron Track Detectors for Boron-10 Microdistribution Measurement in BNCT: A Feasibility Study.

Galuzzi L, Parisi G, Pascali V, Niklas M, Bortot D, Protti N Materials (Basel). 2025; 18(3).

PMID: 39942287 PMC: 11818730. DOI: 10.3390/ma18030621.

Boron neutron capture therapy (BNCT) for liver metastasis in an experimental model: dose–response at five-week follow-up based on retrospective dose assessment in individual rats.

Pozzi E, Trivillin V, Colombo L, Monti Hughes A, Thorp S, Cardoso J Radiat Environ Biophys. 2013; 52(4):481-91.

PMID: 24077963 DOI: 10.1007/s00411-013-0490-9.

Boron neutron capture therapy (BNCT) for liver metastasis: therapeutic efficacy in an experimental model.

Pozzi E, Cardoso J, Colombo L, Thorp S, Monti Hughes A, Molinari A Radiat Environ Biophys. 2012; 51(3):331-9.

PMID: 22544068 DOI: 10.1007/s00411-012-0419-8.

Boron neutron capture therapy (BNCT) for the treatment of liver metastases: biodistribution studies of boron compounds in an experimental model.

Garabalino M, Monti Hughes A, Molinari A, Heber E, Pozzi E, Cardoso J Radiat Environ Biophys. 2010; 50(1):199-207.

PMID: 21132507 DOI: 10.1007/s00411-010-0345-6.