Does Green Tea Affect Postprandial Glucose, Insulin and Satiety in Healthy Subjects: a Randomized Controlled Trial

Overview

Journal Nutr J

Publisher Biomed Central

Specialty Nutritional Sciences

Date 2010 Dec 2

PMID 21118565

Citations 26

Authors

Julija Josic

Anna Tholen Olsson

Jennie Wickeberg

Sandra Lindstedt

Joanna Hlebowicz

Affiliations

Soon will be listed here.

Abstract

Background: Results of epidemiological studies have suggested that consumption of green tea could lower the risk of type 2 diabetes. Intervention studies show that green tea may decrease blood glucose levels, and also increase satiety. This study was conducted to examine the postprandial effects of green tea on glucose levels, glycemic index, insulin levels and satiety in healthy individuals after the consumption of a meal including green tea.

Methods: The study was conducted on 14 healthy volunteers, with a crossover design. Participants were randomized to either 300 ml of green tea or water. This was consumed together with a breakfast consisting of white bread and sliced turkey. Blood samples were drawn at 0, 15, 30, 45, 60, 90, and 120 minutes. Participants completed several different satiety score scales at the same times.

Results: Plasma glucose levels were higher 120 min after ingestion of the meal with green tea than after the ingestion of the meal with water. No significant differences were found in serum insulin levels, or the area under the curve for glucose or insulin. Subjects reported significantly higher satiety, having a less strong desire to eat their favorite food and finding it less pleasant to eat another mouthful of the same food after drinking green tea compared to water.

Conclusions: Green tea showed no glucose or insulin-lowering effect. However, increased satiety and fullness were reported by the participants after the consumption of green tea.

Trial Registration Number: NCT01086189.

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References

Iso H, Date C, Wakai K, Fukui M, Tamakoshi A . The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults. Ann Intern Med. 2006; 144(8):554-62. DOI: 10.7326/0003-4819-144-8-200604180-00005. View

Wellman P . Norepinephrine and the control of food intake. Nutrition. 2000; 16(10):837-42. DOI: 10.1016/s0899-9007(00)00415-9. View

Brand-Miller J, Hayne S, Petocz P, Colagiuri S . Low-glycemic index diets in the management of diabetes: a meta-analysis of randomized controlled trials. Diabetes Care. 2003; 26(8):2261-7. DOI: 10.2337/diacare.26.8.2261. View

Wu L, Juan C, Ho L, Hsu Y, Hwang L . Effect of green tea supplementation on insulin sensitivity in Sprague-Dawley rats. J Agric Food Chem. 2004; 52(3):643-8. DOI: 10.1021/jf030365d. View

MacKenzie T, Leary L, Brooks W . The effect of an extract of green and black tea on glucose control in adults with type 2 diabetes mellitus: double-blind randomized study. Metabolism. 2007; 56(10):1340-4. DOI: 10.1016/j.metabol.2007.05.018. View

Wang X, Law B, Hall R, Nawano M, Granner D . Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production. J Biol Chem. 2002; 277(38):34933-40. DOI: 10.1074/jbc.M204672200. View

Shimizu M, Kobayashi Y, Suzuki M, Satsu H, Miyamoto Y . Regulation of intestinal glucose transport by tea catechins. Biofactors. 2001; 13(1-4):61-5. DOI: 10.1002/biof.5520130111. View

Wentzlaff T, Guss J, Kissileff H . Subjective ratings as a function of amount consumed: a preliminary report. Physiol Behav. 1995; 57(6):1209-14. DOI: 10.1016/0031-9384(95)00017-d. View

Rossi L, Mazzitelli S, Arciello M, Capo C, Rotilio G . Benefits from dietary polyphenols for brain aging and Alzheimer's disease. Neurochem Res. 2008; 33(12):2390-400. DOI: 10.1007/s11064-008-9696-7. View

10.

Haber G, Heaton K, Murphy D, BURROUGHS L . Depletion and disruption of dietary fibre. Effects on satiety, plasma-glucose, and serum-insulin. Lancet. 1977; 2(8040):679-82. DOI: 10.1016/s0140-6736(77)90494-9. View

11.

Flint A, Raben A, Blundell J, Astrup A . Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes Relat Metab Disord. 2000; 24(1):38-48. DOI: 10.1038/sj.ijo.0801083. View

12.

Brown A, Lane J, Coverly J, Stocks J, Jackson S, Stephen A . Effects of dietary supplementation with the green tea polyphenol epigallocatechin-3-gallate on insulin resistance and associated metabolic risk factors: randomized controlled trial. Br J Nutr. 2008; 101(6):886-94. PMC: 2819662. DOI: 10.1017/S0007114508047727. View

13.

Wu L, Juan C, Hwang L, Hsu Y, Ho P, Ho L . Green tea supplementation ameliorates insulin resistance and increases glucose transporter IV content in a fructose-fed rat model. Eur J Nutr. 2004; 43(2):116-24. DOI: 10.1007/s00394-004-0450-x. View

14.

Higdon J, Frei B . Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. Crit Rev Food Sci Nutr. 2003; 43(1):89-143. DOI: 10.1080/10408690390826464. View

15.

Naslund E, Hellstrom P . Appetite signaling: from gut peptides and enteric nerves to brain. Physiol Behav. 2007; 92(1-2):256-62. DOI: 10.1016/j.physbeh.2007.05.017. View

16.

Tsuneki H, Ishizuka M, Terasawa M, Wu J, Sasaoka T, Kimura I . Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans. BMC Pharmacol. 2004; 4:18. PMC: 517497. DOI: 10.1186/1471-2210-4-18. View

17.

Venables M, Hulston C, Cox H, Jeukendrup A . Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans. Am J Clin Nutr. 2008; 87(3):778-84. DOI: 10.1093/ajcn/87.3.778. View

18.

Park J, Jin J, Baek W, Park S, Sung H, Kim Y . Ambivalent role of gallated catechins in glucose tolerance in humans: a novel insight into non-absorbable gallated catechin-derived inhibitors of glucose absorption. J Physiol Pharmacol. 2010; 60(4):101-9. View

19.

Auvichayapat P, Prapochanung M, Tunkamnerdthai O, Sripanidkulchai B, Auvichayapat N, Thinkhamrop B . Effectiveness of green tea on weight reduction in obese Thais: A randomized, controlled trial. Physiol Behav. 2007; 93(3):486-91. DOI: 10.1016/j.physbeh.2007.10.009. View

20.

Brouns F, Bjorck I, Frayn K, Gibbs A, Lang V, Slama G . Glycaemic index methodology. Nutr Res Rev. 2008; 18(1):145-71. DOI: 10.1079/NRR2005100. View