Biologically Active Constituents from the Fruiting Body of Taiwanofungus Camphoratus

Overview

Journal Bioorg Med Chem

Specialties Biochemistry
Chemistry

Date 2010 Dec 1

PMID 21115251

Citations 15

Authors

Li-Shian Shi

Chih-Hua Chao

De-Yang Shen

Hsiu-Hui Chan

Chou-Hsiung Chen

Yu-Ren Liao

Shwu-Jen Wu

Yann-Lii Leu

Yuh-Chiang Shen

Yao-Haur Kuo

E-Jian Lee

Keduo Qian

Tian-Shung Wu

Kuo-Hsiung Lee

Affiliations

Soon will be listed here.

Abstract

Five new benzenoids, benzocamphorins A-E (1-5), and 10 recently isolated triterpenoids, camphoratins A-J (16-25), together with 23 known compounds including seven benzenoids (6-12), three lignans (13-15), and 13 triterpenoids (26-38) were isolated from the fruiting body of Taiwanofungus camphoratus. Their structures were established by spectroscopic analysis. Selected compounds were examined for cytotoxic and anti-inflammatory activities. Compounds 9 and 21 showed moderate cytotoxicity against MCF-7 and Hep2 cell lines with ED(50) values of 3.4 and 3.0μg/mL, respectively. Compounds 21, 25, 26, 29-31, 33, and 36 demonstrated potent anti-inflammatory activity by inhibiting lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC(50) values of 2.5, 1.6, 3.6, 0.6, 4.1, 4.2, 2.5, and 1.5μM, respectively, which were better than those of the nonspecific nitric oxide synthase (NOS) inhibitor N-nitro-l-arginine methyl ester (l-NAME) (IC(50): 25.8μM). These results may substantiate the use of T. camphoratus in traditional Chinese medicine (TCM) for the treatment of inflammation and cancer-related diseases. The newly discovered compounds deserve further development as anti-inflammatory candidates.

Citing Articles

Unlocking the biological potential of methyl antcinate A: a new frontier in cancer and inflammation application.

Sharif M, Irfan M, Kousar K, Mamurova A, Duarte-Pena L, Hernandez-Parra H Naunyn Schmiedebergs Arch Pharmacol. 2024; .

PMID: 39630281 DOI: 10.1007/s00210-024-03544-3.

The alkynyl-containing compounds from mushrooms and their biological activities.

Qi J, Duan Y, Li Z, Gao J, Qi J, Liu C Nat Prod Bioprospect. 2023; 13(1):50.

PMID: 37946001 PMC: 10636002. DOI: 10.1007/s13659-023-00416-w.

Synthesis and Antiproliferative Activity of Triphenylphosphonium Derivatives of Natural Allylpolyalkoxybenzenes.

Tsyganov D, Samet A, Silyanova E, Ushkarov V, Varakutin A, Chernysheva N ACS Omega. 2022; 7(4):3369-3383.

PMID: 35128247 PMC: 8811894. DOI: 10.1021/acsomega.1c05515.

Constituents from the Fruiting Bodies of and in Vietnam and Their Anti-Inflammatory Bioactivity.

Li Y, Ngan N, Cheng K, Hwang T, Thang T, Tuan N Molecules. 2021; 26(23).

PMID: 34885893 PMC: 8659016. DOI: 10.3390/molecules26237311.

Chemoreversal Agents from Taiwanofungus Genus and Their More Potent Methyl Derivatives Targeting Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation.

Yu K, Hung C, Wu T, Chen C, Wu I, Kuo P Pharmaceuticals (Basel). 2021; 14(9).

PMID: 34577615 PMC: 8464893. DOI: 10.3390/ph14090916.

References

Wu S, Leu Y, Chen C, Chao C, Shen D, Chan H . Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus. J Nat Prod. 2010; 73(11):1756-62. PMC: 2993773. DOI: 10.1021/np1002143. View

Lin L, Wang Y, Hou Y, Chang S, Liou K, Chou Y . The inhibitory effect of phenylpropanoid glycosides and iridoid glucosides on free radical production and beta2 integrin expression in human leucocytes. J Pharm Pharmacol. 2006; 58(1):129-35. DOI: 10.1211/jpp.58.1.0016. View

Liou K, Shen Y, Chen C, Tsao C, Tsai S . The anti-inflammatory effect of honokiol on neutrophils: mechanisms in the inhibition of reactive oxygen species production. Eur J Pharmacol. 2003; 475(1-3):19-27. DOI: 10.1016/s0014-2999(03)02121-6. View

Chen J, Lin W, Liao C, Shieh P . Anti-inflammatory benzenoids from Antrodia camphorata. J Nat Prod. 2007; 70(6):989-92. DOI: 10.1021/np070045e. View

Quang D, Bach D . Ergosta-4,6,8(14),22-tetraen-3-one from Vietnamese Xylaria sp. possessing inhibitory activity of nitric oxide production. Nat Prod Res. 2008; 22(10):901-6. DOI: 10.1080/14786410701642706. View

Chen C, Yang S, Shen Y . New steroid acids from Antrodia cinnamomea, a fungal parasite of Cinnamomum micranthum. J Nat Prod. 1995; 58(11):1655-61. DOI: 10.1021/np50125a002. View

Hu S, Xu S, Yao X, Cui C, Tezuka Y, Kikuchi T . Dauricoside, a new glycosidal alkaloid having an inhibitory activity against blood-platelet aggregation. Chem Pharm Bull (Tokyo). 1993; 41(10):1866-8. DOI: 10.1248/cpb.41.1866. View

Wang Y, Wang W, Chang C, Liou K, Sung Y, Liao J . Taxifolin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-oxidative effect and modulation of NF-kappa B activation. J Biomed Sci. 2005; 13(1):127-41. DOI: 10.1007/s11373-005-9031-0. View

Rao Y, Fang S, Tzeng Y . Evaluation of the anti-inflammatory and anti-proliferation tumoral cells activities of Antrodia camphorata, Cordyceps sinensis, and Cinnamomum osmophloeum bark extracts. J Ethnopharmacol. 2007; 114(1):78-85. DOI: 10.1016/j.jep.2007.07.028. View

10.

van den Worm E, Beukelman C, van den Berg A, Kroes B, Labadie R, Van Dijk H . Effects of methoxylation of apocynin and analogs on the inhibition of reactive oxygen species production by stimulated human neutrophils. Eur J Pharmacol. 2002; 433(2-3):225-30. DOI: 10.1016/s0014-2999(01)01516-3. View

11.

Rosecke J, Konig W . Constituents of the fungi Daedalea quercina and Daedaleopsis confragosa var. tricolor. Phytochemistry. 2000; 54(8):757-62. DOI: 10.1016/s0031-9422(00)00130-8. View

12.

Shen Y, Wang S, Pan Y, Lo K, Chakraborty R, Chien C . New taxane diterpenoids from the leaves and twigs of Taxus sumatrana. J Nat Prod. 2002; 65(12):1848-52. DOI: 10.1021/np0202273. View

13.

Liu D, Liang H, Chen C, Su C, Lee T, Huang C . Comparative anti-inflammatory characterization of wild fruiting body, liquid-state fermentation, and solid-state culture of Taiwanofungus camphoratus in microglia and the mechanism of its action. J Ethnopharmacol. 2007; 113(1):45-53. DOI: 10.1016/j.jep.2007.03.037. View