Alpha 2.0
Login Register
» Articles » PMID: 2110152

A Transferable Plasmid Associated with AS-48 Production in Enterococcus Faecalis

Overview
Journal J Bacteriol
Publisher American Society for Microbiology
Specialty Microbiology
Date 1990 May 1
PMID 2110152
Citations 22
Authors
M Martinez-Bueno
A Galvez
E Valdivia
M Maqueda
Affiliations
Soon will be listed here.
Abstract

Enterococcus faecalis S-48 produces a peptide antibiotic, AS-48, and a bacteriocin, Bc-48. We have isolated mutants that lack these inhibitory characteristics. Further analysis of the mutants indicates that a plasmid of 56 kilobases (pMB2) may harbor the genes for AS-48. In conjugation experiments, pMB2 has been transferred into a plasmid-free OG1X strain of E. faecalis. The OG1X(pMB2) transconjugant produces the antibiotic AS-48 in solid medium, and the MIC of AS-48 for this strain is the same as that of the donor strain.

Citing Articles

spp. as a Producer and Target of Bacteriocins: A Double-Edged Sword in the Antimicrobial Resistance Crisis Context.

Almeida-Santos A, Novais C, Peixe L, Freitas A Antibiotics (Basel). 2021; 10(10).

PMID: 34680796 PMC: 8532689. DOI: 10.3390/antibiotics10101215.

Enterocin Cross-Resistance Mediated by ABC Transport Systems.

Teso-Perez C, Martinez-Bueno M, Peralta-Sanchez J, Valdivia E, Maqueda M, Farez-Vidal M Microorganisms. 2021; 9(7).

PMID: 34208875 PMC: 8306556. DOI: 10.3390/microorganisms9071411.

Bioinformatic prospecting and phylogenetic analysis reveals 94 undescribed circular bacteriocins and key motifs.

Vezina B, Rehm B, Smith A BMC Microbiol. 2020; 20(1):77.

PMID: 32252629 PMC: 7132975. DOI: 10.1186/s12866-020-01772-0.

Interbacterial mechanisms of colonization resistance and the strategies pathogens use to overcome them.

Sorbara M, Pamer E Mucosal Immunol. 2018; 12(1):1-9.

PMID: 29988120 PMC: 6312114. DOI: 10.1038/s41385-018-0053-0.

Genome-guided identification of novel head-to-tail cyclized antimicrobial peptides, exemplified by the discovery of pumilarin.

van Heel A, Montalban-Lopez M, Oliveau Q, Kuipers O Microb Genom. 2017; 3(10):e000134.

PMID: 29177092 PMC: 5695211. DOI: 10.1099/mgen.0.000134.

References
1.
Macrina F, Kopecko D, Jones K, Ayers D, McCowen S . A multiple plasmid-containing Escherichia coli strain: convenient source of size reference plasmid molecules. Plasmid. 1978; 1(3):417-20. DOI: 10.1016/0147-619x(78)90056-2. View
2.
Ike Y, Craig R, White B, Yagi Y, Clewell D . Modification of Streptococcus faecalis sex pheromones after acquisition of plasmid DNA. Proc Natl Acad Sci U S A. 1983; 80(17):5369-73. PMC: 384257. DOI: 10.1073/pnas.80.17.5369. View
3.
Anderson D, McKay L . Simple and rapid method for isolating large plasmid DNA from lactic streptococci. Appl Environ Microbiol. 1983; 46(3):549-52. PMC: 239314. DOI: 10.1128/aem.46.3.549-552.1983. View
4.
Galvez A, Valdivia E, Maqueda M, Montoya E . Production of bacteriocin-like substances by group D streptococci of human origin. Microbios. 1985; 43(176S):223-32. View
5.
Galvez A, Valdivia E, Martinez M, Maqueda M . Effect of peptide AS-48 on Enterococcus faecalis subsp. liquefaciens S-47. Antimicrob Agents Chemother. 1989; 33(5):641-5. PMC: 172505. DOI: 10.1128/AAC.33.5.641. View