RTEL1: an Essential Helicase for Telomere Maintenance and the Regulation of Homologous Recombination

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 2010 Nov 25

PMID 21097466

Citations 63

Authors

Evert-Jan Uringa

Jillian L Youds

Kathleen Lisaingo

Peter M Lansdorp

Simon J Boulton

Affiliations

Soon will be listed here.

Abstract

Telomere maintenance and DNA repair are crucial processes that protect the genome against instability. RTEL1, an essential iron-sulfur cluster-containing helicase, is a dominant factor that controls telomere length in mice and is required for telomere integrity. In addition, RTEL1 promotes synthesis-dependent strand annealing to direct DNA double-strand breaks into non-crossover outcomes during mitotic repair and in meiosis. Here, we review the role of RTEL1 in telomere maintenance and homologous recombination and discuss models linking RTEL1's enzymatic activity to its function in telomere maintenance and DNA repair.

Citing Articles

A comprehensive in silico investigation into the pathogenic SNPs in the RTEL1 gene and their biological consequences.

Tanshee R, Mahmud Z, Nabi A, Sayem M PLoS One. 2024; 19(9):e0309713.

PMID: 39240887 PMC: 11379182. DOI: 10.1371/journal.pone.0309713.

Single-stranded DNA binding protein hitches a ride with the YoaA-χ helicase.

Weeks-Pollenz S, Petrides M, Davis R, Harris K, Bloom L bioRxiv. 2024; .

PMID: 38948847 PMC: 11213134. DOI: 10.1101/2024.06.21.600097.

High expression of RTEL1 predicates worse progression in gliomas and promotes tumorigenesis through JNK/ELK1 cascade.

Wang G, Ren X, Li J, Cui R, Zhao X, Sui F BMC Cancer. 2024; 24(1):385.

PMID: 38532312 PMC: 10967111. DOI: 10.1186/s12885-024-12134-8.

Structural Motifs at the Telomeres and Their Role in Regulatory Pathways.

Alanazi A, Parkinson G, Haider S Biochemistry. 2024; 63(7):827-842.

PMID: 38481135 PMC: 10993422. DOI: 10.1021/acs.biochem.4c00023.

Harmonin homology domain-mediated interaction of RTEL1 helicase with RPA and DNA provides insights into its recruitment to DNA repair sites.

Kumar N, Taneja A, Ghosh M, Rothweiler U, Sundaresan N, Singh M Nucleic Acids Res. 2023; 52(3):1450-1470.

PMID: 38153196 PMC: 10853778. DOI: 10.1093/nar/gkad1208.

References

Wicky C, Alpi A, Passannante M, Rose A, Gartner A, Muller F . Multiple genetic pathways involving the Caenorhabditis elegans Bloom's syndrome genes him-6, rad-51, and top-3 are needed to maintain genome stability in the germ line. Mol Cell Biol. 2004; 24(11):5016-27. PMC: 416432. DOI: 10.1128/MCB.24.11.5016-5027.2004. View

Bai C, Connolly B, Metzker M, Hilliard C, Liu X, Sandig V . Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster. Proc Natl Acad Sci U S A. 2000; 97(3):1230-5. PMC: 15578. DOI: 10.1073/pnas.97.3.1230. View

Ghosh A, Rossi M, Aulds J, Croteau D, Bohr V . Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1. J Biol Chem. 2009; 284(45):31074-84. PMC: 2781507. DOI: 10.1074/jbc.M109.027532. View

Andressoo J, Hoeijmakers J . Transcription-coupled repair and premature ageing. Mutat Res. 2005; 577(1-2):179-94. DOI: 10.1016/j.mrfmmm.2005.04.004. View

Wrensch M, Jenkins R, Chang J, Yeh R, Xiao Y, Decker P . Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility. Nat Genet. 2009; 41(8):905-8. PMC: 2923561. DOI: 10.1038/ng.408. View

de Lange T . T-loops and the origin of telomeres. Nat Rev Mol Cell Biol. 2004; 5(4):323-9. DOI: 10.1038/nrm1359. View

Burr B, Burr F, Matz E, Romero-Severson J . Pinning down loose ends: mapping telomeres and factors affecting their length. Plant Cell. 1992; 4(8):953-60. PMC: 160187. DOI: 10.1105/tpc.4.8.953. View

Ward J, Muzzini D, Petalcorin M, Martinez-Perez E, Martin J, Plevani P . Overlapping mechanisms promote postsynaptic RAD-51 filament disassembly during meiotic double-strand break repair. Mol Cell. 2010; 37(2):259-72. DOI: 10.1016/j.molcel.2009.12.026. View

Kim M, Vankayalapati H, Shin-Ya K, Wierzba K, Hurley L . Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex. J Am Chem Soc. 2002; 124(10):2098-9. DOI: 10.1021/ja017308q. View

10.

Fairman-Williams M, Guenther U, Jankowsky E . SF1 and SF2 helicases: family matters. Curr Opin Struct Biol. 2010; 20(3):313-24. PMC: 2916977. DOI: 10.1016/j.sbi.2010.03.011. View

11.

Bugreev D, Yu X, Egelman E, Mazin A . Novel pro- and anti-recombination activities of the Bloom's syndrome helicase. Genes Dev. 2007; 21(23):3085-94. PMC: 2081975. DOI: 10.1101/gad.1609007. View

12.

Xu Y, Suzuki Y, Ito K, Komiyama M . Telomeric repeat-containing RNA structure in living cells. Proc Natl Acad Sci U S A. 2010; 107(33):14579-84. PMC: 2930462. DOI: 10.1073/pnas.1001177107. View

13.

Jones G . The control of chiasma distribution. Symp Soc Exp Biol. 1984; 38:293-320. View

14.

Wolski S, Kuper J, Hanzelmann P, Truglio J, Croteau D, Van Houten B . Crystal structure of the FeS cluster-containing nucleotide excision repair helicase XPD. PLoS Biol. 2008; 6(6):e149. PMC: 2435149. DOI: 10.1371/journal.pbio.0060149. View

15.

Zhao Y, Tarailo-Graovac M, ONeil N, Rose A . Spectrum of mutational events in the absence of DOG-1/FANCJ in Caenorhabditis elegans. DNA Repair (Amst). 2008; 7(11):1846-54. DOI: 10.1016/j.dnarep.2008.07.011. View

16.

Cromie G, Hyppa R, Taylor A, Zakharyevich K, Hunter N, Smith G . Single Holliday junctions are intermediates of meiotic recombination. Cell. 2006; 127(6):1167-78. PMC: 2803030. DOI: 10.1016/j.cell.2006.09.050. View

17.

Sun H, Karow J, Hickson I, Maizels N . The Bloom's syndrome helicase unwinds G4 DNA. J Biol Chem. 1998; 273(42):27587-92. DOI: 10.1074/jbc.273.42.27587. View

18.

Shin-Ya K, Wierzba K, Matsuo K, Ohtani T, Yamada Y, Furihata K . Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus. J Am Chem Soc. 2001; 123(6):1262-3. DOI: 10.1021/ja005780q. View

19.

Starling J, Maule J, Hastie N, Allshire R . Extensive telomere repeat arrays in mouse are hypervariable. Nucleic Acids Res. 1990; 18(23):6881-8. PMC: 332745. DOI: 10.1093/nar/18.23.6881. View

20.

London T, Barber L, Mosedale G, Kelly G, Balasubramanian S, Hickson I . FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts. J Biol Chem. 2008; 283(52):36132-9. PMC: 2662291. DOI: 10.1074/jbc.M808152200. View