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Chaperone-mediated Autophagy in Protein Quality Control

Overview
Publisher Elsevier
Specialty Cell Biology
Date 2010 Nov 25
PMID 21094035
Citations 152
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Abstract

Chaperone-mediated autophagy is a selective mechanism for degradation of soluble cytosolic proteins in lysosomes that distinguishes itself from other autophagic pathways by the selectivity with which CMA substrates are targeted for degradation. The recent molecular dissection of this autophagic pathway and the development of experimental models with compromised CMA have unveiled the important contribution of this pathway to protein quality control. In fact, CMA activation seems to be a common mechanism of cellular defense against proteotoxicity.

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