Cardiac Gene Therapy

Overview

Journal Semin Thorac Cardiovasc Surg

Specialties Cardiology & Vascular Diseases
General Surgery
Pulmonary Medicine

Date 2010 Nov 25

PMID 21092890

Citations 7

Authors

Antoine H Chaanine

Jill Kalman

Roger J Hajjar

Affiliations

Soon will be listed here.

Abstract

Heart failure is a chronic progressive disorder in which frequent and recurrent hospitalizations are associated with high mortality and morbidity. The incidence and the prevalence of this disease will increase with the increase in the number of the aging population of the United States. Understanding the molecular pathology and pathophysiology of this disease will uncover novel targets and therapies that can restore the function or attenuate the damage of malfunctioning cardiomyocytes by gene therapy that becomes an interesting and a promising field for the treatment of heart failure as well as other diseases in the future. Of equal importance are developing vectors and delivery methods that can efficiently transduce most of the cardiomyocytes that can offer a long-term expression and that can escape the host immune response. Recombinant adeno-associated virus vectors have the potential to become a promising novel therapeutic vehicles for molecular medicine in the future.

Citing Articles

Upregulation of miR-128 Mediates Heart Injury by Activating Wnt/β-catenin Signaling Pathway in Heart Failure Mice.

Li J, Li X, Tang Y Organogenesis. 2021; 17(3-4):27-39.

PMID: 34965835 PMC: 9208784. DOI: 10.1080/15476278.2021.2020018.

Using Acellular Bioactive Extracellular Matrix Scaffolds to Enhance Endogenous Cardiac Repair.

Svystonyuk D, Mewhort H, Fedak P Front Cardiovasc Med. 2018; 5:35.

PMID: 29696148 PMC: 5904207. DOI: 10.3389/fcvm.2018.00035.

Optimizing Cardiac Delivery of Modified mRNA.

Sultana N, Magadum A, Hadas Y, Kondrat J, Singh N, Youssef E Mol Ther. 2017; 25(6):1306-1315.

PMID: 28389322 PMC: 5474881. DOI: 10.1016/j.ymthe.2017.03.016.

An attenuated coxsackievirus b3 vector: a potential tool for viral tracking study and gene delivery.

Zeng J, Chen X, Dai J, Zhao X, Xin G, Su Y PLoS One. 2014; 8(12):e83753.

PMID: 24386270 PMC: 3875476. DOI: 10.1371/journal.pone.0083753.

Cathepsin-L ameliorates cardiac hypertrophy through activation of the autophagy-lysosomal dependent protein processing pathways.

Sun M, Ouzounian M, de Couto G, Chen M, Yan R, Fukuoka M J Am Heart Assoc. 2013; 2(2):e000191.

PMID: 23608608 PMC: 3647266. DOI: 10.1161/JAHA.113.000191.

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