Antoine H Chaanine
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Explore the profile of Antoine H Chaanine including associated specialties, affiliations and a list of published articles.
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25
Citations
803
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Recent Articles
1.
White 3rd D, Lauterboeck L, Mobasheran P, Kitaguchi T, Chaanine A, Yang Q
Cells
. 2023 Mar;
12(5).
PMID: 36899830
Adenosine 5' triphosphate (ATP) is the energy currency of life, which is produced in mitochondria (~90%) and cytosol (less than 10%). Real-time effects of metabolic changes on cellular ATP dynamics...
2.
Upadhrasta S, Museedi A, Thannoun T, Chaanine A, Le Jemtel T
Cardiol Rev
. 2023 Feb;
31(4):215-218.
PMID: 36730923
Reversal of cardiogenic shock depends on its early recognition and prompt initiation of therapy. Recognition of the clinical and hemodynamic deterioration that precedes cardiogenic shock is a crucial step in...
3.
Urina Jassir D, Chaanine A, Desai S, Rajapreyar I, Le Jemtel T
Am J Med
. 2022 Oct;
136(1):27-32.
PMID: 36252709
Sepsis is an increasing cause of decompensation in patients with chronic heart failure with reduced or preserved ejection fraction. Sepsis and decompensated heart failure results in a mixed septic-cardiogenic shock...
4.
Chaanine A, Higgins L, Lauterboeck L, Markowski T, Yang Q, Delafontaine P
Cells
. 2022 May;
11(9).
PMID: 35563877
Previous work showed a role of BNIP3 in myocardial remodeling and progression to HFrEF. We utilized a multiomics approach to unravel BNIP3-related molecular mechanisms in the pathogenesis of HFrEF. BNIP3...
5.
Chaanine A, Higgins L, Markowski T, Harman J, Kachman M, Burant C, et al.
Int J Mol Sci
. 2022 Jan;
23(1).
PMID: 35008662
Metabolic remodeling plays an important role in the pathophysiology of heart failure (HF). We sought to characterize metabolic remodeling and implicated signaling pathways in two rat models of early systolic...
6.
Chaanine A
Int J Mol Sci
. 2021 Oct;
22(19).
PMID: 34638917
The heart is an organ with high-energy demands in which the mitochondria are most abundant. They are considered the powerhouse of the cell and occupy a central role in cellular...
7.
Chaanine A, Lejemtel T, Delafontaine P
J Clin Med
. 2020 Nov;
9(11).
PMID: 33172082
The mitochondria are mostly abundant in the heart, a beating organ of high- energy demands. Their function extends beyond being a power plant of the cell including redox balance, ion...
8.
Chaanine A, Navar L, Delafontaine P
J Vis Exp
. 2020 May;
(158).
PMID: 32420983
In response to an injury, such as myocardial infarction, prolonged hypertension or a cardiotoxic agent, the heart initially adapts through the activation of signal transduction pathways, to counteract, in the...
9.
Chaanine A
Medicina (Kaunas)
. 2019 Jun;
55(6).
PMID: 31163678
: Derangements in mitochondrial integrity and function constitute an important pathophysiological feature in the pathogenesis of heart failure (HF) and play an important role in myocardial remodeling and systolic dysfunction....
10.
Chaanine A, Joyce L, Stulak J, Maltais S, Joyce D, Dearani J, et al.
Circ Heart Fail
. 2019 Feb;
12(2):e005131.
PMID: 30744415
Background: The FOXO3a (forkhead box O3a)-BNIP3 (B-cell lymphoma 2/adenovirus E1B 19kDa interacting protein 3) pathway modulates mitochondrial dynamics and function and contributes to myocardial remodeling in rodent models of heart...