Skeletal Myoblasts for Cardiac Repair

Overview

Journal Regen Med

Specialty Biotechnology

Date 2010 Nov 19

PMID 21082891

Citations 39

Authors

Shazia Durrani

Mikhail Konoplyannikov

Muhammad Ashraf

Khawaja Husnain Haider

Affiliations

Soon will be listed here.

Abstract

Stem cells provide an alternative curative intervention for the infarcted heart by compensating for the cardiomyocyte loss subsequent to myocardial injury. The presence of resident stem and progenitor cell populations in the heart, and nuclear reprogramming of somatic cells with genetic induction of pluripotency markers are the emerging new developments in stem cell-based regenerative medicine. However, until safety and feasibility of these cells are established by extensive experimentation in in vitro and in vivo experimental models, skeletal muscle-derived myoblasts, and bone marrow cells remain the most well-studied donor cell types for myocardial regeneration and repair. This article provides a critical review of skeletal myoblasts as donor cells for transplantation in the light of published experimental and clinical data, and indepth discussion of the advantages and disadvantages of skeletal myoblast-based therapeutic intervention for augmentation of myocardial function in the infarcted heart. Furthermore, strategies to overcome the problems of arrhythmogenicity and failure of the transplanted skeletal myoblasts to integrate with the host cardiomyocytes are discussed.

Citing Articles

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Remodeled eX vivo muscle engineered tissue improves heart function after chronic myocardial ischemia.

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Preclinical Large Animal Porcine Models for Cardiac Regeneration and Its Clinical Translation: Role of hiPSC-Derived Cardiomyocytes.

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Recent Advances in Cell Sheet Engineering: From Fabrication to Clinical Translation.

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References

Kim H, Lee Y, Sivaprasad U, Malhotra A, Dutta A . Muscle-specific microRNA miR-206 promotes muscle differentiation. J Cell Biol. 2006; 174(5):677-87. PMC: 2064311. DOI: 10.1083/jcb.200603008. View

Halbach M, Pfannkuche K, Pillekamp F, Ziomka A, Hannes T, Reppel M . Electrophysiological maturation and integration of murine fetal cardiomyocytes after transplantation. Circ Res. 2007; 101(5):484-92. DOI: 10.1161/CIRCRESAHA.107.153643. View

Soonpaa M, Field L . Assessment of cardiomyocyte DNA synthesis in normal and injured adult mouse hearts. Am J Physiol. 1997; 272(1 Pt 2):H220-6. DOI: 10.1152/ajpheart.1997.272.1.H220. View

Siminiak T, Kalawski R, Fiszer D, Jerzykowska O, Rzezniczak J, Rozwadowska N . Autologous skeletal myoblast transplantation for the treatment of postinfarction myocardial injury: phase I clinical study with 12 months of follow-up. Am Heart J. 2004; 148(3):531-7. DOI: 10.1016/j.ahj.2004.03.043. View

Hata H, Matsumiya G, Miyagawa S, Kondoh H, Kawaguchi N, Matsuura N . Grafted skeletal myoblast sheets attenuate myocardial remodeling in pacing-induced canine heart failure model. J Thorac Cardiovasc Surg. 2006; 132(4):918-24. DOI: 10.1016/j.jtcvs.2006.01.024. View

Haider H, Jiang S, Ye L, Aziz S, Law P, Sim E . Effectiveness of transient immunosuppression using cyclosporine for xenomyoblast transplantation for cardiac repair. Transplant Proc. 2004; 36(1):232-5. DOI: 10.1016/j.transproceed.2003.11.001. View

Ye L, Haider H, Esa W, Su L, Law P, Zhang W . Liposome-based vascular endothelial growth factor-165 transfection with skeletal myoblast for treatment of ischaemic limb disease. J Cell Mol Med. 2008; 14(1-2):323-36. PMC: 3837621. DOI: 10.1111/j.1582-4934.2008.00454.x. View

Gavira J, Herreros J, Perez A, Garcia-Velloso M, Barba J, Martin-Herrero F . Autologous skeletal myoblast transplantation in patients with nonacute myocardial infarction: 1-year follow-up. J Thorac Cardiovasc Surg. 2006; 131(4):799-804. DOI: 10.1016/j.jtcvs.2005.11.030. View

Anderson C, Catoe H, Werner R . MIR-206 regulates connexin43 expression during skeletal muscle development. Nucleic Acids Res. 2006; 34(20):5863-71. PMC: 1635318. DOI: 10.1093/nar/gkl743. View

10.

Frangogiannis N . The immune system and cardiac repair. Pharmacol Res. 2008; 58(2):88-111. PMC: 2642482. DOI: 10.1016/j.phrs.2008.06.007. View

11.

Lafreniere J, Caron M, Skuk D, Goulet M, Cheikh A, Tremblay J . Growth factor coinjection improves the migration potential of monkey myogenic precursors without affecting cell transplantation success. Cell Transplant. 2009; 18(7):719-30. DOI: 10.3727/096368909X470900. View

12.

Hassink R, Pasumarthi K, Nakajima H, Rubart M, Soonpaa M, de la Riviere A . Cardiomyocyte cell cycle activation improves cardiac function after myocardial infarction. Cardiovasc Res. 2007; 78(1):18-25. PMC: 2653079. DOI: 10.1093/cvr/cvm101. View

13.

Freund C, Mummery C . Prospects for pluripotent stem cell-derived cardiomyocytes in cardiac cell therapy and as disease models. J Cell Biochem. 2009; 107(4):592-9. DOI: 10.1002/jcb.22164. View

14.

Mias C, Lairez O, Trouche E, Roncalli J, Calise D, Seguelas M . Mesenchymal stem cells promote matrix metalloproteinase secretion by cardiac fibroblasts and reduce cardiac ventricular fibrosis after myocardial infarction. Stem Cells. 2009; 27(11):2734-43. DOI: 10.1002/stem.169. View

15.

Tatsumi R, Hattori A, Ikeuchi Y, Anderson J, Allen R . Release of hepatocyte growth factor from mechanically stretched skeletal muscle satellite cells and role of pH and nitric oxide. Mol Biol Cell. 2002; 13(8):2909-18. PMC: 117951. DOI: 10.1091/mbc.e02-01-0062. View

16.

Skuk D, Goulet M, Tremblay J . Use of repeating dispensers to increase the efficiency of the intramuscular myogenic cell injection procedure. Cell Transplant. 2006; 15(7):659-63. DOI: 10.3727/000000006783981648. View

17.

Ott H, Kroess R, Bonaros N, Marksteiner R, Margreiter E, Schachner T . Intramyocardial microdepot injection increases the efficacy of skeletal myoblast transplantation. Eur J Cardiothorac Surg. 2005; 27(6):1017-21. DOI: 10.1016/j.ejcts.2005.01.065. View

18.

Chachques J, Herreros J, Trainini J, Juffe A, Rendal E, Prosper F . Autologous human serum for cell culture avoids the implantation of cardioverter-defibrillators in cellular cardiomyoplasty. Int J Cardiol. 2004; 95 Suppl 1:S29-33. DOI: 10.1016/s0167-5273(04)90009-5. View

19.

Takahashi K, Yamanaka S . Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006; 126(4):663-76. DOI: 10.1016/j.cell.2006.07.024. View

20.

Winitsky S, Gopal T, Hassanzadeh S, Takahashi H, Gryder D, Rogawski M . Adult murine skeletal muscle contains cells that can differentiate into beating cardiomyocytes in vitro. PLoS Biol. 2005; 3(4):e87. PMC: 1064849. DOI: 10.1371/journal.pbio.0030087. View