The Essence of Senescence

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2010 Nov 17

PMID 21078816

Citations 1041

Authors

Thomas Kuilman

Chrysiis Michaloglou

Wolter J Mooi

Daniel S Peeper

Affiliations

Soon will be listed here.

Abstract

Almost half a century after the first reports describing the limited replicative potential of primary cells in culture, there is now overwhelming evidence for the existence of "cellular senescence" in vivo. It is being recognized as a critical feature of mammalian cells to suppress tumorigenesis, acting alongside cell death programs. Here, we review the various features of cellular senescence and discuss their contribution to tumor suppression. Additionally, we highlight the power and limitations of the biomarkers currently used to identify senescent cells in vitro and in vivo.

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