Role of 4-hydroxy-trans-2-nonenal in Cell Functions

Overview

Journal Biochemistry (Mosc)

Specialty Biochemistry

Date 2010 Nov 17

PMID 21077827

Citations 29

Authors

E E Dubinina

V A Dadali

Affiliations

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Abstract

The role of lipid peroxidation product 4-hydroxy-trans-2-nonenal (4-HNE) in functional activity of cells under normal and different pathological conditions is discussed. Different pathways of 4-HNE metabolism in tissues are analyzed, with particular focus on the role the glutathione system in this process. 4-HNE is implicated in regulation of cell growth, proliferation, differentiation, and apoptosis. 4-HNE and metabolic products of other antioxidants (carotenoids) resemble each other in chemical nature of the product and influence general pathways of signal transduction. Manifestation of 4-HNE toxicity under oxidative stress conditions is regarded as a link to many diseases whose pathogenesis is connected with modifications of proteins and nucleic acids.

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