Propagation of Epileptiform Activity on a Submillimeter Scale

Overview

Journal J Clin Neurophysiol

Specialties Neurology
Physiology

Date 2010 Nov 16

PMID 21076338

Citations 35

Authors

C A Schevon

R R Goodman

G McKhann Jr

R G Emerson

Affiliations

Soon will be listed here.

Abstract

Microseizures are highly focal low-frequency epileptiform-appearing events recorded from the neocortex of epilepsy patients. Because of their tiny, often submillimeter distribution, they may be regarded as a high-resolution window into the epileptic process, providing an excellent opportunity to study the fine temporal structure of their origin and spread. A 16 mm² 96-microelectrode array with 400-μm interelectrode spacing was implanted in seven patients undergoing invasive EEG monitoring for medically refractory epilepsy. Seven microdischarge populations were tested for a substantial contribution by volume conduction to the observed waveform amplitudes. Single-unit activity was examined for specific evidence of neural activity at multiple sites within the microdischarge fields. We found that microdischarges appear to originate at a highly focal source location, likely within a single cortical macrocolumn, and spread to local and more distant sites via neural propagation.

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References

Schevon C, Trevelyan A, Schroeder C, Goodman R, McKhann Jr G, Emerson R . Spatial characterization of interictal high frequency oscillations in epileptic neocortex. Brain. 2009; 132(Pt 11):3047-59. PMC: 2768661. DOI: 10.1093/brain/awp222. View

Dominguez L, Wennberg R, Gaetz W, Cheyne D, Snead 3rd O, Perez Velazquez J . Enhanced synchrony in epileptiform activity? Local versus distant phase synchronization in generalized seizures. J Neurosci. 2005; 25(35):8077-84. PMC: 6725453. DOI: 10.1523/JNEUROSCI.1046-05.2005. View

Wennberg R, Lozano A . Intracranial volume conduction of cortical spikes and sleep potentials recorded with deep brain stimulating electrodes. Clin Neurophysiol. 2003; 114(8):1403-18. DOI: 10.1016/s1388-2457(03)00152-4. View

Schevon C, Ng S, Cappell J, Goodman R, McKhann Jr G, Waziri A . Microphysiology of epileptiform activity in human neocortex. J Clin Neurophysiol. 2008; 25(6):321-30. PMC: 2967462. DOI: 10.1097/WNP.0b013e31818e8010. View

Lachaux J, Rudrauf D, Kahane P . Intracranial EEG and human brain mapping. J Physiol Paris. 2004; 97(4-6):613-28. DOI: 10.1016/j.jphysparis.2004.01.018. View

Shipp S . Structure and function of the cerebral cortex. Curr Biol. 2007; 17(12):R443-9. DOI: 10.1016/j.cub.2007.03.044. View

Bautista R, Cobbs M, Spencer D, Spencer S . Prediction of surgical outcome by interictal epileptiform abnormalities during intracranial EEG monitoring in patients with extrahippocampal seizures. Epilepsia. 1999; 40(7):880-90. DOI: 10.1111/j.1528-1157.1999.tb00794.x. View

Alarcon G, Seoane J, Binnie C, Martin Miguel M, Juler J, Polkey C . Origin and propagation of interictal discharges in the acute electrocorticogram. Implications for pathophysiology and surgical treatment of temporal lobe epilepsy. Brain. 1998; 120 ( Pt 12):2259-82. DOI: 10.1093/brain/120.12.2259. View

Zaveri H, Duckrow R, Spencer S . Concerning the observation of an electrical potential at a distance from an intracranial electrode contact. Clin Neurophysiol. 2009; 120(10):1873-5. DOI: 10.1016/j.clinph.2009.08.001. View

10.

House P, MacDonald J, Tresco P, Normann R . Acute microelectrode array implantation into human neocortex: preliminary technique and histological considerations. Neurosurg Focus. 2006; 20(5):E4. DOI: 10.3171/foc.2006.20.5.5. View

11.

Waziri A, Schevon C, Cappell J, Emerson R, McKhann 2nd G, Goodman R . Initial surgical experience with a dense cortical microarray in epileptic patients undergoing craniotomy for subdural electrode implantation. Neurosurgery. 2009; 64(3):540-5. PMC: 3039544. DOI: 10.1227/01.NEU.0000337575.63861.10. View

12.

Xu W, Huang X, Takagaki K, Wu J . Compression and reflection of visually evoked cortical waves. Neuron. 2007; 55(1):119-29. PMC: 1988694. DOI: 10.1016/j.neuron.2007.06.016. View

13.

Massimini M, Huber R, Ferrarelli F, Hill S, Tononi G . The sleep slow oscillation as a traveling wave. J Neurosci. 2004; 24(31):6862-70. PMC: 6729597. DOI: 10.1523/JNEUROSCI.1318-04.2004. View

14.

Ulbert I, Heit G, Madsen J, Karmos G, Halgren E . Laminar analysis of human neocortical interictal spike generation and propagation: current source density and multiunit analysis in vivo. Epilepsia. 2004; 45 Suppl 4:48-56. DOI: 10.1111/j.0013-9580.2004.04011.x. View

15.

Rosenow F, Luders H . Presurgical evaluation of epilepsy. Brain. 2001; 124(Pt 9):1683-700. DOI: 10.1093/brain/124.9.1683. View

16.

Hochberg L, Serruya M, Friehs G, Mukand J, Saleh M, Caplan A . Neuronal ensemble control of prosthetic devices by a human with tetraplegia. Nature. 2006; 442(7099):164-71. DOI: 10.1038/nature04970. View

17.

Schwartzkroin P, Knowles W . Intracellular study of human epileptic cortex: in vitro maintenance of epileptiform activity?. Science. 1984; 223(4637):709-12. DOI: 10.1126/science.6695179. View

18.

Emerson R, Turner C, Pedley T, Walczak T, Forgione M . Propagation patterns of temporal spikes. Electroencephalogr Clin Neurophysiol. 1995; 94(5):338-48. DOI: 10.1016/0013-4694(94)00316-d. View

19.

Suner S, Fellows M, Vargas-Irwin C, Nakata G, Donoghue J . Reliability of signals from a chronically implanted, silicon-based electrode array in non-human primate primary motor cortex. IEEE Trans Neural Syst Rehabil Eng. 2006; 13(4):524-41. DOI: 10.1109/TNSRE.2005.857687. View