» Articles » PMID: 21075328

Targeting Chemokine (C-C Motif) Ligand 2 (CCL2) As an Example of Translation of Cancer Molecular Biology to the Clinic

Overview
Specialty Molecular Biology
Date 2010 Nov 16
PMID 21075328
Citations 54
Authors
Affiliations
Soon will be listed here.
Abstract

Chemokines are a family of small and secreted proteins that play pleiotropic roles in inflammation-related pathological diseases, including cancer. Among the identified 50 human chemokines, chemokine (C-C motif) ligand 2 (CCL2) is of particular importance in cancer development since it serves as one of the key mediators of interactions between tumor and host cells. CCL2 is produced by cancer cells and multiple different host cells within the tumor microenvironment. CCL2 mediates tumorigenesis in many different cancer types. For example, CCL2 has been reported to promote prostate cancer cell proliferation, migration, invasion, and survival, via binding to its functional receptor CCR2. Furthermore, CCL2 induces the recruitment of macrophages and induces angiogenesis and matrix remodeling. Targeting CCL2 has been demonstrated as an effective therapeutic approach in preclinical prostate cancer models, and currently, neutralizing monoclonal antibody against CCL2 has entered into clinical trials in prostate cancer. In this chapter, targeting CCL2 in prostate cancer will be used as an example to show translation of laboratory findings from cancer molecular biology to the clinic.

Citing Articles

C-C Motif Chemokine Ligand 2 and Chemokine Receptor 2 in Cardiovascular and Neural Aging and Aging-Related Diseases.

Guo D, Zhu W, Qiu H Int J Mol Sci. 2024; 25(16).

PMID: 39201480 PMC: 11355023. DOI: 10.3390/ijms25168794.


Focal Adhesion Kinase and Colony Stimulating Factors: Intestinal Homeostasis and Innate Immunity Crosstalk.

Brown N, Vomhof-DeKrey E Cells. 2024; 13(14.

PMID: 39056760 PMC: 11274384. DOI: 10.3390/cells13141178.


Delayed CCL23 response is associated with poor outcomes after cardiac arrest.

deKay J, Chepurko E, Chepurko V, Knudsen L, Lord C, Searight M Cytokine. 2024; 176:156536.

PMID: 38325139 PMC: 10915974. DOI: 10.1016/j.cyto.2024.156536.


Dietary exposure of the water flea to microcystin-LR.

Kim E, Jeon D, Park Y, Woo H, Eyun S Anim Cells Syst (Seoul). 2024; 28(1):25-36.

PMID: 38298818 PMC: 10829830. DOI: 10.1080/19768354.2024.2302529.


A Systems Biology Approach for Investigating Significant Biomarkers and Drug Targets Common Among Patients with Gonorrhea, Chlamydia, and Prostate Cancer: A Pilot Study.

Noman A, Islam M, Feroz T, Hossain M, Shakil M Bioinform Biol Insights. 2023; 17:11779322231214445.

PMID: 38033384 PMC: 10683397. DOI: 10.1177/11779322231214445.


References
1.
Liao J, Li X, Koh A, Berry J, Thudi N, Rosol T . Tumor expressed PTHrP facilitates prostate cancer-induced osteoblastic lesions. Int J Cancer. 2008; 123(10):2267-78. PMC: 3979464. DOI: 10.1002/ijc.23602. View

2.
Gonzalo J, Lloyd C, Wen D, Albar J, Wells T, Proudfoot A . The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness. J Exp Med. 1998; 188(1):157-67. PMC: 2525544. DOI: 10.1084/jem.188.1.157. View

3.
Hu H, Sun L, Guo C, Liu Q, Zhou Z, Peng L . Tumor cell-microenvironment interaction models coupled with clinical validation reveal CCL2 and SNCG as two predictors of colorectal cancer hepatic metastasis. Clin Cancer Res. 2009; 15(17):5485-93. DOI: 10.1158/1078-0432.CCR-08-2491. View

4.
Balkwill F . Chemokine biology in cancer. Semin Immunol. 2002; 15(1):49-55. DOI: 10.1016/s1044-5323(02)00127-6. View

5.
Kim M, Day C, Selinger C, Magno C, Stephens S, Morrison N . MCP-1-induced human osteoclast-like cells are tartrate-resistant acid phosphatase, NFATc1, and calcitonin receptor-positive but require receptor activator of NFkappaB ligand for bone resorption. J Biol Chem. 2005; 281(2):1274-85. DOI: 10.1074/jbc.M510156200. View