Inorganic Nanoparticle-based Contrast Agents for Molecular Imaging

Overview

Journal Trends Mol Med

Specialties General Medicine
Molecular Biology

Date 2010 Nov 16

PMID 21074494

Citations 55

Authors

Eun Chul Cho

Charles Glaus

Jingyi Chen

Michael J Welch

Younan Xia

Affiliations

Soon will be listed here.

Abstract

Inorganic nanoparticles (NPs) including semiconductor quantum dots (QDs), iron oxide NPs and gold NPs have been developed as contrast agents for diagnostics by molecular imaging. Compared with traditional contrast agents, NPs offer several advantages: their optical and magnetic properties can be tailored by engineering the composition, structure, size and shape; their surfaces can be modified with ligands to target specific biomarkers of disease; the contrast enhancement provided can be equivalent to millions of molecular counterparts; and they can be integrated with a combination of different functions for multimodal imaging. Here, we review recent advances in the development of contrast agents based on inorganic NPs for molecular imaging, and also touch on contrast enhancement, surface modification, tissue targeting, clearance and toxicity. As research efforts intensify, contrast agents based on inorganic NPs that are highly sensitive, target-specific and safe to use are expected to enter clinical applications in the near future.

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