The Effects of Postnatal Estrogen Therapy on Brain Development in Preterm Baboons

Overview

Journal Am J Obstet Gynecol

Publisher Elsevier

Specialty Gynecology & Obstetrics

Date 2010 Nov 16

PMID 21074139

Citations 3

Authors

Sandra Rees

Michelle Loeliger

Amy Shields

Philip W Shaul

Donald McCurnin

Bradley Yoder

Terrie Inder

Affiliations

Soon will be listed here.

Abstract

Objective: Estrogen receptors are present within the fetal brain, suggesting that estrogens may exert an influence on cerebral development. Loss of placentally derived estrogen in preterm birth may impair development.

Study Design: Baboons were delivered at 125 days of gestation (term approximately 185 days), randomly allocated to receive estradiol (n = 10) or placebo (n = 8), and ventilated for 14 days. Brains were assessed for developmental and neuropathological parameters.

Results: Body and brain weights were not different between groups, but the brain/body weight ratio was increased (P < .05) in estradiol-treated animals. There were no differences (P > .05) between groups in any neuropathological measure in either the forebrain or cerebellum. There were no intraventricular hemorrhages; 1 estradiol animal displayed ectactic vessels in the subarachnoid space.

Conclusion: Brief postnatal estradiol administration to primates does not pose an increased risk of injury or impaired brain development.

Citing Articles

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Animal models of bronchopulmonary dysplasia. The preterm baboon models.

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