Effect of Ductus Ligation on Cardiopulmonary Function in Premature Baboons

Overview

Journal Am J Respir Crit Care Med

Specialty Critical Care

Date 2005 Sep 24

PMID 16179644

Citations 18

Authors

Donald C McCurnin

Bradley A Yoder

Jacqueline Coalson

Peter Grubb

Jay Kerecman

John Kupferschmid

Chris Breuer

Theresa Siler-Khodr

Philip W Shaul

Ronald Clyman

Affiliations

Soon will be listed here.

Abstract

Rationale: The role of the patent ductus arteriosus in the development of chronic lung disease in surfactant-treated premature newborns remains unclear.

Objective: To examine the effects of ductus ligation on cardiopulmonary function and lung histopathology in premature primates.

Methods: Baboons were delivered at 125 d, (term = 185 d) treated with surfactant, and ventilated for 14 d. Serial echocardiograms and pulmonary function tests were performed. Animals were randomized to ligation (n = 12) or no ligation (controls, n = 13) on Day 6 of life. Necropsy was performed on Day 14.

Results: Compared with nonligated control animals, ligated animals had lower pulmonary-to-systemic flow ratios, higher systemic blood pressures, and improved indices of right and left ventricular performance. The ligated animals tended to have better compliance and ventilation indices for the last 3 d of the study. There were no differences between the groups in proinflammatory tracheal cytokines (interleukin [IL] 6 and IL-8), static lung compliance, or lung histology.

Conclusion: Although a persistent patent ductus arteriosus results in diminished cardiac function and increased ventilatory requirements at the end of the second week of life, ligation on Day 6 had no measurable effect on the histologic evolution of chronic lung injury in this 14-d baboon model.

Citing Articles

Pulmonary Function and Systolic Blood Pressure in Very Low Birth Weight Infants at 34 - 36 Weeks of Corrected Age.

Gievers L, Jenkins R, Laird A, Macedo M, Schilling D, McEvoy C Res Rep Neonatol. 2021; 9:21-30.

PMID: 34084063 PMC: 8171237. DOI: 10.2147/rrn.s208194.

Lung function in very low birth weight infants after pharmacological and surgical treatment of patent ductus arteriosus - a retrospective analysis.

Barikbin P, Sallmon H, Wilitzki S, Photiadis J, Buhrer C, Koehne P BMC Pediatr. 2017; 17(1):5.

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Liver disease after intensive care of premature baboons: histopathologic observations.

Kerecman J, Mehrotra A, Goodman Z J Pediatr Gastroenterol Nutr. 2013; 57(2):172-9.

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The role of patent ductus arteriosus and its treatments in the development of bronchopulmonary dysplasia.

Clyman R Semin Perinatol. 2013; 37(2):102-7.

PMID: 23582964 PMC: 3627220. DOI: 10.1053/j.semperi.2013.01.006.

Hyperglycemia increases the risk of death in extremely preterm baboons.

Blanco C, McGill-Vargas L, McCurnin D, Quinn A Pediatr Res. 2013; 73(3):337-43.

PMID: 23364173 PMC: 4112412. DOI: 10.1038/pr.2012.184.

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