Differential Fatty Acid Profile in Adipose and Non-adipose Tissues in Obese Mice

Overview

Journal Int J Clin Exp Med

Specialty General Medicine

Date 2010 Nov 13

PMID 21072264

Citations 10

Authors

Mengting Li

Weisi Fu

Xiang-An Li

Affiliations

Soon will be listed here.

Abstract

Obesity is a metabolic disease characterized by chronic inflammation. Early studies indicated that adipose tissue from obese mice contains more saturated fatty acids and that the saturated fatty acids activate TLR4-mediated inflammatory signaling, which contributes to inflammation in adipose tissue. In this study, we determined fatty acid profile in non-adipose tissues from obese (db/db) mice and compared with that from lean mice. Unexpectedly, in contrast to a significant increase in saturated and decrease in unsaturated fatty acid in adipose tissue from obese mice, the non-adipose tissues from obese mice exhibited a significant decrease in saturated and increase in unsaturated fatty acid compared with that from lean mice. The liver from obese mice had a 15% and 32% decrease in palmitic acid and stearic acid, and a 20% increase in linoleic acid; the spleen had a 32% and 60% decrease in palmitic acid and stearic acid, and a 70% and 50% increase in oleic acid and linoleic acid; and the pancreas had a 50% and 75% decrease in palmitic acid and stearic acid, and a 130% and 113% increase in oleic acid and linoleic acid. These data suggest that, different from adipose tissue where elevated saturated fatty acids contributes to inflammation, fatty acids per se in non-adipose tissues such as liver, spleen and pancreas may not contribute to inflammatory responses in obese mice.

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