HIV-1 Nef Protein Visits B-cells Via Macrophage Nanotubes: a Mechanism for AIDS-related Lymphoma Pathogenesis?

Overview

Journal Curr HIV Res

Publisher Bentham Science Publishers

Date 2010 Nov 12

PMID 21067513

Citations 7

Authors

Susanna L Lamers

Gary B Fogel

Leanne C Huysentruyt

Michael S McGrath

Affiliations

Soon will be listed here.

Abstract

This letter refers to the recent demonstration that HIV-1 infected macrophages form specialized conduits that connect to B-cells (1). The conduit selectively transports the HIV-1 nef protein, providing nef with numerous means to interfere with cellular processes. Currently, no consideration of the connection between the conduit and the development of AIDS-related lymphoma (ARL) has been offered. ARL is one of the primary causes of death in the HIV-infected population and is related to B-cell proliferation and activation. In this letter we discuss several studies that link HIV-infected macrophages and specific forms of the nef protein to the development of ARL. The conduits discovered by Xu et al. may lead to a better understanding of how HIV infection results in lymphomagenesis.

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