Hesperidin, a Flavanone Glycoside, on Lipid Peroxidation and Antioxidant Status in Experimental Myocardial Ischemic Rats

Overview

Journal Redox Rep

Specialties Biochemistry
Biology
Endocrinology

Date 2010 Nov 11

PMID 21062537

Citations 20

Authors

Palanisamy Selvaraj

Kodukkur Viswanathan Pugalendi

Affiliations

Soon will be listed here.

Abstract

Myocardial infarction continues to be a leading cause of mortality world-wide. Novel therapies are needed to treat the myocardial ischemia. This study was undertaken to evaluate the cardioprotective role of hesperidin on isoproterenol-induced myocardial ischemia in rats. Myocardial ischemia was induced by subcutaneous injection of isoproterenol hydrochloride (85 mg/kg body weight), for two consecutive days. Isoproterenol-administered rats showed elevated levels of cardiac markers (aspartate transaminase, alanine transaminase, lactate dehydrogenase, creatine kinase, creatine kinase-MB, cardiac troponins T and I) when compared with control and hesperidin treatment groups (100, 200 and 400 mg/kg body weight). The serum levels of cardiac markers were significantly reduced at the doses of 200 mg and 400 mg. All further experiments were carried out at the 200 mg dose. Lipid peroxidation markers (thiobarbituric acid reactive substances, lipid hydroperoxides and conjugated dienes) were elevated significantly in the plasma and heart whereas non-enzymic antioxidants (vitamin C, vitamin E and reduced glutathione) were decreased significantly. Activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and glutathione reductase declined significantly in the heart of ischemic rats. However, after hesperidin treatment, all the above parameters reverted to normal levels. This study demonstrated that the cardioprotective effect of hesperidin on ischemic rats could be due to its anti-lipid peroxidative and antioxidant properties.

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References

Karthikeyan K, Bai B, Niranjali Devaraj S . Cardioprotective effect of grape seed proanthocyanidins on isoproterenol-induced myocardial injury in rats. Int J Cardiol. 2006; 115(3):326-33. DOI: 10.1016/j.ijcard.2006.03.016. View

Kim J, Jung K, Choi J, Young Chung H . Hesperetin: a potent antioxidant against peroxynitrite. Free Radic Res. 2004; 38(7):761-9. DOI: 10.1080/10715760410001713844. View

Singh N, Dhalla A, Seneviratne C, Singal P . Oxidative stress and heart failure. Mol Cell Biochem. 1995; 147(1-2):77-81. DOI: 10.1007/BF00944786. View

Rathore N, John S, Kale M, Bhatnagar D . Lipid peroxidation and antioxidant enzymes in isoproterenol induced oxidative stress in rat tissues. Pharmacol Res. 1998; 38(4):297-303. DOI: 10.1006/phrs.1998.0365. View

PINTO R, Bartley W . The effect of age and sex on glutathione reductase and glutathione peroxidase activities and on aerobic glutathione oxidation in rat liver homogenates. Biochem J. 1969; 112(1):109-15. PMC: 1187646. DOI: 10.1042/bj1120109. View

Rotruck J, POPE A, Ganther H, SWANSON A, Hafeman D, Hoekstra W . Selenium: biochemical role as a component of glutathione peroxidase. Science. 1973; 179(4073):588-90. DOI: 10.1126/science.179.4073.588. View

Larue C, Calzolari C, Bertinchant J, Leclercq F, Grolleau R, Pau B . Cardiac-specific immunoenzymometric assay of troponin I in the early phase of acute myocardial infarction. Clin Chem. 1993; 39(6):972-9. View

Abidi P, Afaq F, Arif J, Lohani M, Rahman Q . Chrysotile-mediated imbalance in the glutathione redox system in the development of pulmonary injury. Toxicol Lett. 1999; 106(1):31-9. DOI: 10.1016/s0378-4274(99)00013-2. View

Sinha A . Colorimetric assay of catalase. Anal Biochem. 1972; 47(2):389-94. DOI: 10.1016/0003-2697(72)90132-7. View

10.

Balakrishnan A, Menon V . Antioxidant properties of hesperidin in nicotine-induced lung toxicity. Fundam Clin Pharmacol. 2007; 21(5):535-46. DOI: 10.1111/j.1472-8206.2007.00477.x. View

11.

Tappia P, Hata T, Hozaima L, Sandhu M, Panagia V, Dhalla N . Role of oxidative stress in catecholamine-induced changes in cardiac sarcolemmal Ca2+ transport. Arch Biochem Biophys. 2001; 387(1):85-92. DOI: 10.1006/abbi.2000.2234. View

12.

Katus H, Remppis A, Neumann F, Scheffold T, DIEDERICH K, Vinar G . Diagnostic efficiency of troponin T measurements in acute myocardial infarction. Circulation. 1991; 83(3):902-12. DOI: 10.1161/01.cir.83.3.902. View

13.

Coles B, Ketterer B . The role of glutathione and glutathione transferases in chemical carcinogenesis. Crit Rev Biochem Mol Biol. 1990; 25(1):47-70. DOI: 10.3109/10409239009090605. View

14.

Ellman G . Tissue sulfhydryl groups. Arch Biochem Biophys. 1959; 82(1):70-7. DOI: 10.1016/0003-9861(59)90090-6. View

15.

Kaur G, Tirkey N, Chopra K . Beneficial effect of hesperidin on lipopolysaccharide-induced hepatotoxicity. Toxicology. 2006; 226(2-3):152-60. DOI: 10.1016/j.tox.2006.06.018. View

16.

Chen Y, Zheng R, Jia Z, Ju Y . Flavonoids as superoxide scavengers and antioxidants. Free Radic Biol Med. 1990; 9(1):19-21. DOI: 10.1016/0891-5849(90)90045-k. View

17.

OKINAKA S, Kumagai H, Ebashi S, Sugita H, Momoi H, TOYOKURA Y . Serum creatine phosphokinase. Activity in progressive muscular dystrophy and neuromuscular diseases. Arch Neurol. 1961; 4:520-5. DOI: 10.1001/archneur.1961.00450110050006. View

18.

Choi S, Benzie I, Collins A, Hannigan B, Strain J . Vitamins C and E: acute interactive effects on biomarkers of antioxidant defence and oxidative stress. Mutat Res. 2004; 551(1-2):109-17. DOI: 10.1016/j.mrfmmm.2004.03.006. View

19.

Acikel M, Buyukokuroglu M, Erdogan F, Aksoy H, Bozkurt E, Senocak H . Protective effects of dantrolene against myocardial injury induced by isoproterenol in rats: biochemical and histological findings. Int J Cardiol. 2005; 98(3):389-94. DOI: 10.1016/j.ijcard.2003.10.054. View

20.

Galati E, Monforte M, KIRJAVAINEN S, Forestieri A, Trovato A, Tripodo M . Biological effects of hesperidin, a citrus flavonoid. (Note I): antiinflammatory and analgesic activity. Farmaco. 1994; 40(11):709-12. View