A Mild Negishi Cross-coupling of 2-heterocyclic Organozinc Reagents and Aryl Chlorides

Overview

Journal J Org Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2010 Nov 5

PMID 21047088

Citations 16

Authors

Michael R Luzung

Jigar S Patel

Jingjun Yin

Affiliations

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Abstract

A mild Negishi cross-coupling of 2-heterocyclic organozinc reagents and aryl chlorides is described. The use of Pd(2)(dba)(3) and X-Phos as a ligand provides high yields for many examples. An efficient method to generate the organozinc reagents at room temperature is also demonstrated.

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