Associations Between the Intake of Caffeinated and Decaffeinated Coffee and Measures of Insulin Sensitivity and Beta Cell Function

Overview

Journal Diabetologia

Specialty Endocrinology

Date 2010 Nov 4

PMID 21046357

Citations 33

Authors

R C Loopstra-Masters

A D Liese

S M Haffner

L E Wagenknecht

A J Hanley

Affiliations

Soon will be listed here.

Abstract

Aims/hypothesis: Although protective relationships between coffee consumption and type 2 diabetes mellitus have consistently been observed, few studies have examined the relationships between coffee consumption and underlying pathophysiological defects that characterise diabetes aetiology. The aim of this study was to explore the associations between caffeinated and decaffeinated coffee consumption and measures of insulin sensitivity and secretion.

Methods: The study population included 954 multi-ethnic non-diabetic adults from the Insulin Resistance Atherosclerosis Study (IRAS). Multiple regression analyses were performed to examine the cross-sectional relationships between caffeinated and decaffeinated coffee intake and insulin sensitivity and acute insulin response, measured by a frequently sampled intravenous glucose tolerance test, 2 h postload glucose measured by OGTT, fasting insulin, and proinsulin to C-peptide ratios.

Results: Caffeinated coffee intake was positively associated with insulin sensitivity (β = 0.054; SE = 0.026; p = 0.04) and inversely related to 2 h postload glucose (β = -0.37; SE = 0.10; p = 0.0003) in fully adjusted models. Caffeinated coffee intake was not associated with acute insulin response or proinsulin ratios. Decaffeinated coffee intake was inversely related to 2 h postload glucose (β = -0.47; SE = 0.18; p = 0.0096) and positively related to acute insulin response (β = 0.191; SE = 0.077; p = 0.0132). Decaffeinated coffee intake was inversely related to the ratios of both intact and split proinsulin to C-peptide (β = -0.150; SE = 0.061; p = 0.0148; β = -0.254; SE = 0.068; p = 0.0002, respectively).

Conclusions/interpretation: In this cross-sectional study, caffeinated coffee was positively related to insulin sensitivity and decaffeinated coffee was favourably related to measures of beta cell function. These results provide pathophysiological insight as to how coffee could impact the risk of type 2 diabetes mellitus.

Citing Articles

Metabolic shifts during coffee consumption refresh the immune response: insight from comprehensive multiomics analysis.

Ruan P, Yang M, Lv X, Shen K, Chen Y, Li H MedComm (2020). 2024; 5(7):e617.

PMID: 38887468 PMC: 11181901. DOI: 10.1002/mco2.617.

Dietary caffeine intake is associated with favorable metabolic profile among apparently healthy overweight and obese individuals.

Alshahrani S, Atia Y, Badir R, Almalki S, Tayyib N, Shahab S BMC Endocr Disord. 2023; 23(1):227.

PMID: 37864190 PMC: 10588058. DOI: 10.1186/s12902-023-01477-1.

Insulinemic potential of diet and risk of total and subtypes of breast cancer among US females.

Romanos-Nanclares A, Tabung F, Willett W, Rosner B, Holmes M, Chen W Am J Clin Nutr. 2022; 116(6):1530-1539.

PMID: 36178066 PMC: 9761760. DOI: 10.1093/ajcn/nqac284.

Healthy beverages may reduce the genetic risk of abdominal obesity and related metabolic comorbidities: a gene-diet interaction study in Iranian women.

Gholami F, Samadi M, Soveid N, Mirzaei K Diabetol Metab Syndr. 2022; 14(1):143.

PMID: 36167582 PMC: 9516810. DOI: 10.1186/s13098-022-00911-z.

Coffee Drinking and Adverse Physical Outcomes in the Aging Adult Population: A Systematic Review.

Mazeaud S, Castellana F, Coelho-Junior H, Panza F, Rondanelli M, Fassio F Metabolites. 2022; 12(7).

PMID: 35888778 PMC: 9318773. DOI: 10.3390/metabo12070654.

References

Sartorelli D, Fagherazzi G, Balkau B, Touillaud M, Boutron-Ruault M, de Lauzon-Guillain B . Differential effects of coffee on the risk of type 2 diabetes according to meal consumption in a French cohort of women: the E3N/EPIC cohort study. Am J Clin Nutr. 2010; 91(4):1002-12. DOI: 10.3945/ajcn.2009.28741. View

van Dam R, Feskens E . Coffee consumption and risk of type 2 diabetes mellitus. Lancet. 2002; 360(9344):1477-8. DOI: 10.1016/S0140-6736(02)11436-X. View

Tuomilehto J, Hu G, Bidel S, Lindstrom J, Jousilahti P . Coffee consumption and risk of type 2 diabetes mellitus among middle-aged Finnish men and women. JAMA. 2004; 291(10):1213-9. DOI: 10.1001/jama.291.10.1213. View

Arnlov J, Vessby B, Riserus U . Coffee consumption and insulin sensitivity. JAMA. 2004; 291(10):1199-201. DOI: 10.1001/jama.291.10.1199-b. View

Carlsson S, Hammar N, Grill V, Kaprio J . Coffee consumption and risk of type 2 diabetes in Finnish twins. Int J Epidemiol. 2004; 33(3):616-7. DOI: 10.1093/ije/dyh185. View

van Dam R, Dekker J, Nijpels G, Stehouwer C, Bouter L, Heine R . Coffee consumption and incidence of impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes: the Hoorn Study. Diabetologia. 2005; 47(12):2152-9. DOI: 10.1007/s00125-004-1573-6. View

Wu T, Willett W, Hankinson S, Giovannucci E . Caffeinated coffee, decaffeinated coffee, and caffeine in relation to plasma C-peptide levels, a marker of insulin secretion, in U.S. women. Diabetes Care. 2005; 28(6):1390-6. DOI: 10.2337/diacare.28.6.1390. View

Dekker M, Gusba J, Robinson L, Graham T . Glucose homeostasis remains altered by acute caffeine ingestion following 2 weeks of daily caffeine consumption in previously non-caffeine-consuming males. Br J Nutr. 2007; 98(3):556-62. DOI: 10.1017/S0007114507730738. View

Huxley R, Lee C, Barzi F, Timmermeister L, Czernichow S, Perkovic V . Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: a systematic review with meta-analysis. Arch Intern Med. 2009; 169(22):2053-63. DOI: 10.1001/archinternmed.2009.439. View

10.

Salazar-Martinez E, Willett W, Ascherio A, Manson J, Leitzmann M, Stampfer M . Coffee consumption and risk for type 2 diabetes mellitus. Ann Intern Med. 2004; 140(1):1-8. DOI: 10.7326/0003-4819-140-1-200401060-00005. View

11.

Hu G, Jousilahti P, Peltonen M, Bidel S, Tuomilehto J . Joint association of coffee consumption and other factors to the risk of type 2 diabetes: a prospective study in Finland. Int J Obes (Lond). 2006; 30(12):1742-9. DOI: 10.1038/sj.ijo.0803341. View

12.

Moisey L, Kacker S, Bickerton A, Robinson L, Graham T . Caffeinated coffee consumption impairs blood glucose homeostasis in response to high and low glycemic index meals in healthy men. Am J Clin Nutr. 2008; 87(5):1254-61. DOI: 10.1093/ajcn/87.5.1254. View

13.

Mayer-Davis E, DAgostino Jr R, Karter A, Haffner S, Rewers M, Saad M . Intensity and amount of physical activity in relation to insulin sensitivity: the Insulin Resistance Atherosclerosis Study. JAMA. 1998; 279(9):669-74. DOI: 10.1001/jama.279.9.669. View

14.

Mayer-Davis E, Vitolins M, Carmichael S, Hemphill S, Tsaroucha G, Rushing J . Validity and reproducibility of a food frequency interview in a Multi-Cultural Epidemiology Study. Ann Epidemiol. 2000; 9(5):314-24. DOI: 10.1016/s1047-2797(98)00070-2. View

15.

Odegaard A, Pereira M, Koh W, Arakawa K, Lee H, Yu M . Coffee, tea, and incident type 2 diabetes: the Singapore Chinese Health Study. Am J Clin Nutr. 2008; 88(4):979-85. PMC: 2737528. DOI: 10.1093/ajcn/88.4.979. View

16.

Tunnicliffe J, Shearer J . Coffee, glucose homeostasis, and insulin resistance: physiological mechanisms and mediators. Appl Physiol Nutr Metab. 2008; 33(6):1290-300. DOI: 10.1139/H08-123. View

17.

Fuhrman B, Smit E, Crespo C, Garcia-Palmieri M . Coffee intake and risk of incident diabetes in Puerto Rican men: results from the Puerto Rico Heart Health Program. Public Health Nutr. 2008; 12(6):842-8. DOI: 10.1017/S1368980008003303. View

18.

Wagenknecht L, Mayer E, Rewers M, Haffner S, SELBY J, Borok G . The insulin resistance atherosclerosis study (IRAS) objectives, design, and recruitment results. Ann Epidemiol. 1995; 5(6):464-72. DOI: 10.1016/1047-2797(95)00062-3. View

19.

van Dam R . Coffee consumption and risk of type 2 diabetes, cardiovascular diseases, and cancer. Appl Physiol Nutr Metab. 2008; 33(6):1269-83. DOI: 10.1139/H08-120. View

20.

Agardh E, Carlsson S, Ahlbom A, Efendic S, Grill V, Hammar N . Coffee consumption, type 2 diabetes and impaired glucose tolerance in Swedish men and women. J Intern Med. 2004; 255(6):645-52. DOI: 10.1111/j.1365-2796.2004.01331.x. View