Structure of Plasmodium Falciparum ADP-ribosylation Factor 1

Overview

Journal Acta Crystallogr Sect F Struct Biol Cryst Commun

Date 2010 Nov 4

PMID 21045287

Citations 6

Authors

William J Cook

Craig D Smith

Olga Senkovich

Anthony A Holder

Debasish Chattopadhyay

Affiliations

Soon will be listed here.

Abstract

Vesicular trafficking may play a crucial role in the pathogenesis and survival of the malaria parasite. ADP-ribosylation factors (ARFs) are among the major components of vesicular trafficking pathways in eukaryotes. The crystal structure of ARF1 GTPase from Plasmodium falciparum has been determined in the GDP-bound conformation at 2.5 Å resolution and is compared with the structures of mammalian ARF1s.

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