Pathogenicity of High-dose Enteral Inoculation of Burkholderia Pseudomallei to Mice

Overview

Journal Am J Trop Med Hyg

Specialty Tropical Medicine

Date 2010 Nov 2

PMID 21036839

Citations 25

Authors

T Eoin West

Nicolle D Myers

Direk Limmathurotsakul

H Denny Liggitt

Narisara Chantratita

Sharon J Peacock

Shawn J Skerrett

Affiliations

Soon will be listed here.

Abstract

Melioidosis is a frequently lethal tropical infection caused by the environmental saprophyte Burkholderia pseudomallei. Although transcutaneous inoculation and inhalation are considered the primary routes of infection, suggestive clinical evidence implicates ingestion as a possible alternative route. We show that in BALB/c and C57BL/6 mice, direct gastric inoculation of high doses of B. pseudomallei causes systemic infection that may be lethal or cause chronic disseminated infection. Mice may shed bacteria in the stool for weeks after infection, and high titers of B. pseudomallei-specific IgG are detectable. This report of enteric murine melioidosis supports further consideration of this route of infection.

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