Bone Loss Rate May Interact with Other Risk Factors for Fractures Among Elderly Women: A 15-Year Population-Based Study

Overview

Journal J Osteoporos

Publisher Wiley

Specialty Orthopedics

Date 2010 Oct 29

PMID 20981330

Citations 1

Authors

Joonas Sirola

Anna-Kaisa Koistinen

Kari Salovaara

Toni Rikkonen

Marjo Tuppurainen

Jukka S Jurvelin

Risto Honkanen

Esko Alhava

Heikki Kroger

Affiliations

Soon will be listed here.

Abstract

Aim was to investigate fracture risk (FR) according to bone loss (BL) rate. A random sample of 1652 women aged 53.5 years was measured with dual X-ray absorptiometry in femoral neck in 1989 and 1994 and divided into tertiles of annual BL rate: high >0.84%, moderate 0.13%-0.84%, and low <0.13%. Low trauma energy fractures during following 10 years were recorded. There were no differences in FR between BL tertiles in Cox regression model. Factors predicting lower FR in Cox model were in high tertile: high T-score (HR 0.71; 95% CI 0.54-0.93, P = .012), no sister's fracture (HR 0.35; 0.19-0.64, P = .001), no mother's fracture (HR 0.52; 0.31-0.88, P = .015), in moderate tertile: high T-score (HR 0.69;0.53-0.91, P = .008) and good grip strength (HR 0.98; 0.97-0.99, P = .022). In low tertile there were no predictors for FR. BL predicted FR in women with mother's fracture in univariate and multivariate model (OR 2.6; 1.15-5.7, P = .021) but with sister's fracture this was observed only in multivariate model (OR 2.66; 1.09-6.7, P = .039). Accordingly, the risk factors for postmenopausal fractures, especially mother's fracture, may interact with BL.

Citing Articles

Association between lifestyle and pathologic fractures in patients admitted to surgery departments of selected hospitals affiliated to Alborz University of Medical Sciences in 2014-2015.

Islami Vaghar M J Family Med Prim Care. 2019; 8(9):2799-2802.

PMID: 31681645 PMC: 6820397. DOI: 10.4103/jfmpc.jfmpc_531_19.

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