Gender Dependence for a Subset of the Low-abundance Signaling Proteome in Human Platelets

Overview

Journal Hum Genomics Proteomics

Specialty Genetics

Date 2010 Oct 29

PMID 20981232

Citations 12

Authors

Ofer Eidelman

Catherine Jozwik

Wei Huang

Meera Srivastava

Stephen W Rothwell

David M Jacobowitz

Xiaoduo Ji

Xiuying Zhang

William Guggino

Jerry Wright

Jeffrey Kiefer

Cara Olsen

Nima Adimi

Gregory P Mueller

Harvey B Pollard

Affiliations

Soon will be listed here.

Abstract

The incidence of cardiovascular diseases is ten-times higher in males than females, although the biological basis for this gender disparity is not known. However, based on the fact that antiplatelet drugs are the mainstay for prevention and therapy, we hypothesized that the signaling proteomes in platelets from normal male donors might be more activated than platelets from normal female donors. We report here that platelets from male donors express significantly higher levels of signaling cascade proteins than platelets from female donors. In silico connectivity analysis shows that the 24 major hubs in platelets from male donors focus on pathways associated with megakaryocytic expansion and platelet activation. By contrast, the 11 major hubs in platelets from female donors were found to be either negative or neutral for platelet-relevant processes. The difference may suggest a biological mechanism for gender discrimination in cardiovascular disease.

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