Mechanisms of HIV Envelope-induced T Lymphocyte Apoptosis

Overview

Journal Virol Sin

Specialty Microbiology

Date 2010 Oct 21

PMID 20960177

Citations 3

Authors

Zhi-Tao Wan

Xu-Lin Chen

Affiliations

Soon will be listed here.

Abstract

Infection by the human immunodeficiency virus (HIV) is characterized by a progressive depletion of CD4 T lymphocytes, which leads to dysfunction of the immune system. Although a variety of mechanisms may contribute to the gradual T cell decline that occurs in HIV-infected patients, abnormal apoptosis of infected or bystander T lymphocytes is an important event leading to immunodeficiency. The HIV envelope glycoprotein plays a crucial role in HIV associated apoptosis through both death receptor-mediated and mitochondria-dependent pathways. This review summarizes current knowledge of Env-mediated T lymphocyte apoptosis.

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