Regulation of CXCR4 Signaling

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 2006 Dec 16

PMID 17169327

Citations 307

Authors

John M Busillo

Jeffrey L Benovic

Affiliations

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Abstract

The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled receptors, and is directly involved in a number of biological processes including organogenesis, hematopoiesis, and immune response. Recent evidence has highlighted the role of CXCR4 in a variety of diseases including HIV, cancer, and WHIM syndrome. Importantly, the involvement of CXCR4 in cancer metastasis and WHIM syndrome appears to be due to dysregulation of the receptor leading to enhanced signaling. Herein we review what is currently known regarding the regulation of CXCR4 and how dysregulation contributes to disease progression.

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