Ivermectin Binds Avidly to Plasma Proteins

Overview

Journal Eur J Clin Pharmacol

Specialty Pharmacology

Date 1990 Jan 1

PMID 2095348

Citations 22

Authors

U Klotz

J E Ogbuokiri

P O Okonkwo

Affiliations

Soon will be listed here.

Abstract

Human pharmacokinetic data on the new anti-parasitic agent, ivermectin, are scanty. For the evaluation of its disposition a specific HPLC assay with sensitive fluorescence detection was developed. Applying equilibrium dialysis, plasma protein binding of ivermectin was measured in five healthy individuals and it averaged 93.2 +/- 4.4% (SD). Such strong binding should be taken into consideration, especially in patients with malnutrition or with diseases in which a decrease in plasma proteins and consequently a higher free fraction of ivermectin could be expected.

Citing Articles

Antiplasmodial and Insecticidal Activities of Third-Generation Ivermectin Hybrids.

Parth , Santana S, Rola C, Oliveira C, Prudencio M, Singh K J Med Chem. 2024; 67(22):20224-20241.

PMID: 39505355 PMC: 11613448. DOI: 10.1021/acs.jmedchem.4c01606.

Safety, pharmacokinetics, and potential neurological interactions of ivermectin, tafenoquine, and chloroquine in Rhesus macaques.

Vanachayangkul P, Kodchakorn C, Ta-Aksorn W, Im-Erbsin R, Tungtaeng A, Tipthara P Antimicrob Agents Chemother. 2024; 68(6):e0018124.

PMID: 38742896 PMC: 11620492. DOI: 10.1128/aac.00181-24.

Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 activity.

Eastman R, Rusinova R, Herold K, Huang X, Dranchak P, Voss T bioRxiv. 2023; .

PMID: 37961094 PMC: 10634736. DOI: 10.1101/2023.10.23.563088.

Computational Prediction of the Interaction of Ivermectin with Fibrinogen.

Vottero P, Tavernini S, Santin A, Scheim D, Tuszynski J, Aminpour M Int J Mol Sci. 2023; 24(14).

PMID: 37511206 PMC: 10380762. DOI: 10.3390/ijms241411449.

Pharmacokinetics of ivermectin metabolites and their activity against Anopheles stephensi mosquitoes.

Kern C, Muller P, Chaccour C, Liechti M, Hammann F, Duthaler U Malar J. 2023; 22(1):194.

PMID: 37355605 PMC: 10290335. DOI: 10.1186/s12936-023-04624-0.

References

Edwards G, Dingsdale A, Helsby N, Orme M, Breckenridge A . The relative systemic availability of ivermectin after administration as capsule, tablet, and oral solution. Eur J Clin Pharmacol. 1988; 35(6):681-4. DOI: 10.1007/BF00637608. View

Awadzi K, Dadzie K, HADDOCK D, GILLES H, Aziz M . The chemotherapy of onchocerciasis X. An assessment of four single dose treatment regimes of MK-933 (ivermectin) in human onchocerciasis. Ann Trop Med Parasitol. 1985; 79(1):63-78. View