A Cellular and Molecular Biology-based Update for Ivermectin Against COVID-19: is It Effective or Non-effective?

Overview

Journal Inflammopharmacology

Specialty Pharmacology

Date 2023 Jan 7

PMID 36609716

Authors

Mohsen Nabi-Afjadi

Fatemeh Mohebi

Hamidreza Zalpoor

Fatemeh Aziziyan

Abdullatif Akbari

Hemen Moradi-Sardareh

Elham Bahreini

Amir Mansour Moeini

Hossein Effatpanah

Affiliations

Soon will be listed here.

Abstract

Despite community vaccination against coronavirus disease 2019 (COVID-19) and reduced mortality, there are still challenges in treatment options for the disease. Due to the continuous mutation of SARS-CoV-2 virus and the emergence of new strains, diversity in the use of existing antiviral drugs to combat the epidemic has become a crucial therapeutic chance. As a broad-spectrum antiparasitic and antiviral drug, ivermectin has traditionally been used to treat many types of disease, including DNA and RNA viral infections. Even so, based on currently available data, it is still controversial that ivermectin can be used as one of the effective antiviral agents to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or not. The aim of this study was to provide comprehensive information on ivermectin, including its safety and efficacy, as well as its adverse effects in the treatment of COVID-19.

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