Marine Polysaccharides in Pharmaceutical Applications: an Overview

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2010 Oct 16

PMID 20948899

Citations 116

Authors

Paola Laurienzo

Affiliations

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Abstract

The enormous variety of polysaccharides that can be extracted from marine plants and animal organisms or produced by marine bacteria means that the field of marine polysaccharides is constantly evolving. Recent advances in biological techniques allow high levels of polysaccharides of interest to be produced in vitro. Biotechnology is a powerful tool to obtain polysaccharides from a variety of micro-organisms, by controlling the growth conditions in a bioreactor while tailoring the production of biologically active compounds. Following an overview of the current knowledge on marine polysaccharides, with special attention to potential pharmaceutical applications and to more recent progress on the discovering of new polysaccharides with biological appealing characteristics, this review will focus on possible strategies for chemical or physical modification aimed to tailor the final properties of interest.

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References

Montanaro L, Arciola C, Cenni E, Ciapetti G, Savioli F, Filippini F . Cytotoxicity, blood compatibility and antimicrobial activity of two cyanoacrylate glues for surgical use. Biomaterials. 2000; 22(1):59-66. DOI: 10.1016/s0142-9612(00)00163-0. View

Iwasaki N, Yamane S, Majima T, Kasahara Y, Minami A, Harada K . Feasibility of polysaccharide hybrid materials for scaffolds in cartilage tissue engineering: evaluation of chondrocyte adhesion to polyion complex fibers prepared from alginate and chitosan. Biomacromolecules. 2004; 5(3):828-33. DOI: 10.1021/bm0400067. View

Strand B, Gaserod O, Kulseng B, Espevik T . Alginate-polylysine-alginate microcapsules: effect of size reduction on capsule properties. J Microencapsul. 2002; 19(5):615-30. DOI: 10.1080/02652040210144243. View

Ma Z, Lim L . Uptake of chitosan and associated insulin in Caco-2 cell monolayers: a comparison between chitosan molecules and chitosan nanoparticles. Pharm Res. 2003; 20(11):1812-9. DOI: 10.1023/b:pham.0000003379.76417.3e. View

Sun C, Shan C, Gao X, Tan R . Protection of PC12 cells from hydrogen peroxide-induced injury by EPS2, an exopolysaccharide from a marine filamentous fungus Keissleriella sp. YS4108. J Biotechnol. 2004; 115(2):137-44. DOI: 10.1016/j.jbiotec.2004.08.011. View

Qurrat-Ul-Ain , Sharma S, Khuller G, Garg S . Alginate-based oral drug delivery system for tuberculosis: pharmacokinetics and therapeutic effects. J Antimicrob Chemother. 2003; 51(4):931-8. DOI: 10.1093/jac/dkg165. View

Shu X, Zhu K . Chitosan/gelatin microspheres prepared by modified emulsification and ionotropic gelation. J Microencapsul. 2001; 18(2):237-45. DOI: 10.1080/02652040010000415. View

Rowley J, Madlambayan G, Mooney D . Alginate hydrogels as synthetic extracellular matrix materials. Biomaterials. 1999; 20(1):45-53. DOI: 10.1016/s0142-9612(98)00107-0. View

Hu S, Jou C, Yang M . Protein adsorption, fibroblast activity and antibacterial properties of poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) grafted with chitosan and chitooligosaccharide after immobilized with hyaluronic acid. Biomaterials. 2003; 24(16):2685-93. DOI: 10.1016/s0142-9612(03)00079-6. View

10.

Holte O, Onsoyen E, Myrvold R, Karlsen J . Sustained release of water-soluble drug from directly compressed alginate tablets. Eur J Pharm Sci. 2003; 20(4-5):403-7. DOI: 10.1016/j.ejps.2003.09.003. View

11.

Hoffmann B, Volkmer E, Kokott A, Augat P, Ohnmacht M, Sedlmayr N . Characterisation of a new bioadhesive system based on polysaccharides with the potential to be used as bone glue. J Mater Sci Mater Med. 2009; 20(10):2001-9. DOI: 10.1007/s10856-009-3782-5. View

12.

Wang Y, Hollingsworth R, Kasper D . Ozonolytic depolymerization of polysaccharides in aqueous solution. Carbohydr Res. 1999; 319(1-4):141-7. DOI: 10.1016/s0008-6215(99)00113-5. View

13.

Shepherd R, Rockey J, Sutherland I, Roller S . Novel bioemulsifiers from microorganisms for use in foods. J Biotechnol. 1995; 40(3):207-17. DOI: 10.1016/0168-1656(95)00053-s. View

14.

Tu R, Lu C, Thyagarajan K, Wang E, Nguyen H, Shen S . Kinetic study of collagen fixation with polyepoxy fixatives. J Biomed Mater Res. 1993; 27(1):3-9. DOI: 10.1002/jbm.820270103. View

15.

Schwartz-Albiez R, Adams Y, von der Lieth C, Mischnick P, Andrews K, Kirschfink M . Regioselectively modified sulfated cellulose as prospective drug for treatment of malaria tropica. Glycoconj J. 2006; 24(1):57-65. DOI: 10.1007/s10719-006-9012-1. View

16.

Shu X, Zhu K . A novel approach to prepare tripolyphosphate/chitosan complex beads for controlled release drug delivery. Int J Pharm. 2000; 201(1):51-8. DOI: 10.1016/s0378-5173(00)00403-8. View

17.

Hu Q, Li B, Wang M, Shen J . Preparation and characterization of biodegradable chitosan/hydroxyapatite nanocomposite rods via in situ hybridization: a potential material as internal fixation of bone fracture. Biomaterials. 2003; 25(5):779-85. DOI: 10.1016/s0142-9612(03)00582-9. View

18.

Duan K, Zhang X, Tang X, Yu J, Liu S, Wang D . Fabrication of cationic nanomicelle from chitosan-graft-polycaprolactone as the carrier of 7-ethyl-10-hydroxy-camptothecin. Colloids Surf B Biointerfaces. 2010; 76(2):475-82. DOI: 10.1016/j.colsurfb.2009.12.007. View

19.

El-Kamel A, Sokar M, Naggar V, Al Gamal S . Chitosan and sodium alginate-based bioadhesive vaginal tablets. AAPS PharmSci. 2003; 4(4):E44. PMC: 2751333. DOI: 10.1208/ps040444. View

20.

Doyle J, Roth T, Smith R, Li Y, Dunn R . Effects of calcium alginate on cellular wound healing processes modeled in vitro. J Biomed Mater Res. 1996; 32(4):561-8. DOI: 10.1002/(SICI)1097-4636(199612)32:4<561::AID-JBM9>3.0.CO;2-P. View