Destroy to Create: E3 Ubiquitin Ligases in Neurogenesis

Overview

Journal F1000 Biol Rep

Specialty Biology

Date 2010 Oct 16

PMID 20948796

Citations 14

Authors

Judith Stegmuller

Azad Bonni

Affiliations

Soon will be listed here.

Abstract

The ubiquitin proteasome system (UPS) has drawn tremendous attention in the field of neuroscience. In recent years, we have gained insights into UPS-dependent mechanisms in brain development and disease. Several interesting studies over the past two years have highlighted the role of distinct E3 ubiquitin ligases in neurogenesis. Here, we will review the major findings in these studies and discuss their implications.

Citing Articles

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Loss of Usp9x disrupts cell adhesion, and components of the Wnt and Notch signaling pathways in neural progenitors.

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E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration.

Upadhyay A, Joshi V, Amanullah A, Mishra R, Arora N, Prasad A Front Mol Neurosci. 2017; 10:151.

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