The Role of TNF Inhibitors in Psoriasis Therapy: New Implications for Associated Comorbidities

Overview

Journal F1000 Med Rep

Specialty General Medicine

Date 2010 Oct 16

PMID 20948750

Citations 30

Authors

John Yost

Johann E Gudjonsson

Affiliations

Soon will be listed here.

Abstract

Over the past several years, tumor necrosis factor (TNF) antagonists have become first-line agents in the treatment of moderate-to-severe psoriasis. These medications are highly effective in treating both psoriasis and psoriatic arthritis and may also reduce the risk of cardiovascular events in patients with chronic inflammatory disorders. In this article we review the use of anti-TNF therapy in psoriasis and its implications in regards to the co-morbid conditions associated with psoriasis.

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References

Barland C, Kerdel F . Addition of low-dose methotrexate to infliximab in the treatment of a patient with severe, recalcitrant pustular psoriasis. Arch Dermatol. 2003; 139(7):949-50. DOI: 10.1001/archderm.139.7.949. View

Saraceno R, Schipani C, Mazzotta A, Esposito M, Di Renzo L, De Lorenzo A . Effect of anti-tumor necrosis factor-alpha therapies on body mass index in patients with psoriasis. Pharmacol Res. 2008; 57(4):290-5. DOI: 10.1016/j.phrs.2008.02.006. View

Clark L, Lebwohl M . The effect of weight on the efficacy of biologic therapy in patients with psoriasis. J Am Acad Dermatol. 2007; 58(3):443-6. DOI: 10.1016/j.jaad.2007.11.011. View

Strober B, Teller C, Yamauchi P, Miller J, Hooper M, Yang Y . Effects of etanercept on C-reactive protein levels in psoriasis and psoriatic arthritis. Br J Dermatol. 2008; 159(2):322-30. DOI: 10.1111/j.1365-2133.2008.08628.x. View

Gottlieb A, Chamian F, Masud S, Cardinale I, Abello M, Lowes M . TNF inhibition rapidly down-regulates multiple proinflammatory pathways in psoriasis plaques. J Immunol. 2005; 175(4):2721-9. DOI: 10.4049/jimmunol.175.4.2721. View

Cawthorn W, Sethi J . TNF-alpha and adipocyte biology. FEBS Lett. 2007; 582(1):117-31. PMC: 4304634. DOI: 10.1016/j.febslet.2007.11.051. View

Briot K, Gossec L, Kolta S, Dougados M, Roux C . Prospective assessment of body weight, body composition, and bone density changes in patients with spondyloarthropathy receiving anti-tumor necrosis factor-alpha treatment. J Rheumatol. 2008; 35(5):855-61. View

Schmitt J, Zhang Z, Wozel G, Meurer M, Kirch W . Efficacy and tolerability of biologic and nonbiologic systemic treatments for moderate-to-severe psoriasis: meta-analysis of randomized controlled trials. Br J Dermatol. 2008; 159(3):513-26. DOI: 10.1111/j.1365-2133.2008.08732.x. View

Gelfand J, Neimann A, Shin D, Wang X, Margolis D, Troxel A . Risk of myocardial infarction in patients with psoriasis. JAMA. 2006; 296(14):1735-41. DOI: 10.1001/jama.296.14.1735. View

10.

Azfar R, Gelfand J . Psoriasis and metabolic disease: epidemiology and pathophysiology. Curr Opin Rheumatol. 2008; 20(4):416-22. PMC: 3746494. DOI: 10.1097/BOR.0b013e3283031c99. View

11.

Gisondi P, Girolomoni G . Biologic therapies in psoriasis: a new therapeutic approach. Autoimmun Rev. 2007; 6(8):515-9. DOI: 10.1016/j.autrev.2006.12.002. View

12.

Zaba L, Cardinale I, Gilleaudeau P, Sullivan-Whalen M, Suarez-Farinas M, Suarez Farinas M . Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses. J Exp Med. 2007; 204(13):3183-94. PMC: 2150965. DOI: 10.1084/jem.20071094. View

13.

Ahmad K, Rogers S . Three years' experience with infliximab in recalcitrant psoriasis. Clin Exp Dermatol. 2006; 31(5):630-3. DOI: 10.1111/j.1365-2230.2006.02170.x. View

14.

Gisondi P, Cotena C, Tessari G, Girolomoni G . Anti-tumour necrosis factor-alpha therapy increases body weight in patients with chronic plaque psoriasis: a retrospective cohort study. J Eur Acad Dermatol Venereol. 2007; 22(3):341-4. DOI: 10.1111/j.1468-3083.2007.02429.x. View

15.

Doherty S, Van Voorhees A, Lebwohl M, Korman N, Young M, Hsu S . National Psoriasis Foundation consensus statement on screening for latent tuberculosis infection in patients with psoriasis treated with systemic and biologic agents. J Am Acad Dermatol. 2008; 59(2):209-17. DOI: 10.1016/j.jaad.2008.03.023. View

16.

Thaci D . Long-term data in the treatment of psoriasis. Br J Dermatol. 2008; 159 Suppl 2:18-24. DOI: 10.1111/j.1365-2133.2008.08781.x. View

17.

Kirby B, Marsland A, Carmichael A, Griffiths C . Successful treatment of severe recalcitrant psoriasis with combination infliximab and methotrexate. Clin Exp Dermatol. 2001; 26(1):27-9. DOI: 10.1046/j.1365-2230.2001.00753.x. View

18.

Gelfand J, Troxel A, Lewis J, Kurd S, Shin D, Wang X . The risk of mortality in patients with psoriasis: results from a population-based study. Arch Dermatol. 2007; 143(12):1493-9. DOI: 10.1001/archderm.143.12.1493. View

19.

Paller A, Siegfried E, Langley R, Gottlieb A, Pariser D, Landells I . Etanercept treatment for children and adolescents with plaque psoriasis. N Engl J Med. 2008; 358(3):241-51. DOI: 10.1056/NEJMoa066886. View

20.

Gelfand J, Shin D, Neimann A, Wang X, Margolis D, Troxel A . The risk of lymphoma in patients with psoriasis. J Invest Dermatol. 2006; 126(10):2194-201. DOI: 10.1038/sj.jid.5700410. View