Adherence to a Mediterranean Diet and Plasma Concentrations of Lipid Peroxidation in Premenopausal Women

Overview

Journal Am J Clin Nutr

Publisher Elsevier

Specialty Nutritional Sciences

Date 2010 Oct 15

PMID 20943796

Citations 33

Authors

Audrey J Gaskins

Alisha J Rovner

Sunni L Mumford

Edwina Yeung

Richard W Browne

Maurizio Trevisan

Neil J Perkins

Jean Wactawski-Wende

Enrique F Schisterman

Affiliations

Soon will be listed here.

Abstract

Background: A Mediterranean diet has been associated with a reduced risk of cardiovascular disease and mortality. A possible mechanism is through a decrease in lipid peroxidation (LPO); however, evidence linking the Mediterranean diet with lower LPO in premenopausal women is sparse.

Objective: We investigated whether adherence to a Mediterranean diet was associated with lower LPO concentrations in premenopausal women.

Design: Two hundred fifty-nine healthy women aged 18-44 y were followed for ≤ 2 menstrual cycles. Plasma concentrations of F(2)-isoprostane (8-iso-PGF2α), 9-hydroxyoctadecadieneoic acid (9-HODE), and thiobarbituric acid reactive substances (TBARS) were measured ≤ 8 times per cycle at visits scheduled by using fertility monitors. Diet was assessed ≤ 4 times per cycle by using 24-h dietary recalls. The alternate Mediterranean Diet Score (aMED) (range: 0-9) was calculated on the basis of intake of vegetables, legumes, fruit, nuts, whole grains, red and processed meat, fish, and alcohol and the ratio of monounsaturated to saturated fat.

Results: A 1-unit increase in aMED was associated with a 4.50% decrease in 8-iso-PGF2α concentrations (95% CI: -6.32%, -2.65%) and a 14.01% decrease in 9-HODE concentrations (95% CI: -17.88%, -9.96%) after adjustment for energy intake, age, race, body mass index, plasma ascorbic acid, and serum cholesterol. No significant association was observed between aMED and TBARS. A 1-unit increase in aMED was associated with a 1.39% increase (95% CI: 0.07%, 2.72%) in plasma ascorbic acid concentrations.

Conclusions: Adherence to a Mediterranean diet is associated with lower LPO and higher ascorbic acid concentrations. These results confirm that decreased LPO is a plausible mechanism linking a Mediterranean diet to reduced cardiovascular disease risk.

Citing Articles

Association between healthy dietary patterns and markers of oxidative stress in the Sister Study.

Crawford B, Steck S, Sandler D, Nichols H, Milne G, Park Y Eur J Nutr. 2023; 63(2):485-499.

PMID: 38070016 DOI: 10.1007/s00394-023-03280-z.

Mediterranean Diet Adherence and Depressive Symptoms among a Nationally Representative Sample of Pregnant Women in the United States.

Oddo V, Moise C, Welke L, Penalver Bernabe B, Maki P, Koenig M J Nutr. 2023; 153(10):3041-3048.

PMID: 37598749 PMC: 10613757. DOI: 10.1016/j.tjnut.2023.08.022.

Antioxidant Nutrients and Risk of Latent Autoimmune Diabetes in Adults and Type 2 Diabetes: A Swedish Case-Control Study and Mendelian Randomization Analysis.

Lampousi A, Lofvenborg J, Ahlqvist E, Tuomi T, Wolk A, Carlsson S Nutrients. 2023; 15(11).

PMID: 37299509 PMC: 10255589. DOI: 10.3390/nu15112546.

The Relationship of Preconception and Early Pregnancy Isoprostanes with Fecundability and Pregnancy Loss.

Nobles C, Mendola P, Mumford S, Silver R, Kim K, Perkins N Epidemiology. 2023; 34(5):759-766.

PMID: 37255247 PMC: 10525006. DOI: 10.1097/EDE.0000000000001631.

Adherence to a Mediterranean Diet Is Associated with Lower Depressive Symptoms among U.S. Adults.

Oddo V, Welke L, McLeod A, Pezley L, Xia Y, Maki P Nutrients. 2022; 14(2).

PMID: 35057462 PMC: 8780598. DOI: 10.3390/nu14020278.

References

Armstrong D, Browne R . The analysis of free radicals, lipid peroxides, antioxidant enzymes and compounds related to oxidative stress as applied to the clinical chemistry laboratory. Adv Exp Med Biol. 1994; 366:43-58. DOI: 10.1007/978-1-4615-1833-4_4. View

Eckel R, Howard B, St Jeor S, Bazzarre T . AHA Science Advisory: Lyon Diet Heart Study. Benefits of a Mediterranean-style, National Cholesterol Education Program/American Heart Association Step I Dietary Pattern on Cardiovascular Disease. Circulation. 2001; 103(13):1823-5. DOI: 10.1161/01.cir.103.13.1823. View

Browne R, Armstrong D . Simultaneous determination of serum retinol, tocopherols, and carotenoids by HPLC. Methods Mol Biol. 1999; 108:269-75. DOI: 10.1385/0-89603-472-0:269. View

Sokol R, Heubi J, Iannaccone S, Bove K, Balistreri W . Vitamin E deficiency with normal serum vitamin E concentrations in children with chronic cholestasis. N Engl J Med. 1984; 310(19):1209-12. DOI: 10.1056/NEJM198405103101901. View

Levine M, Conry-Cantilena C, Wang Y, Welch R, Washko P, Dhariwal K . Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci U S A. 1996; 93(8):3704-9. PMC: 39676. DOI: 10.1073/pnas.93.8.3704. View

Hagfors L, Leanderson P, Skoldstam L, Andersson J, Johansson G . Antioxidant intake, plasma antioxidants and oxidative stress in a randomized, controlled, parallel, Mediterranean dietary intervention study on patients with rheumatoid arthritis. Nutr J. 2003; 2:5. PMC: 194256. DOI: 10.1186/1475-2891-2-5. View

Pitsavos C, Panagiotakos D, Trichopoulou A, Chrysohoou C, Dedoussis G, Chloptsios Y . Interaction between Mediterranean diet and methylenetetrahydrofolate reductase C677T mutation on oxidized low density lipoprotein concentrations: the ATTICA study. Nutr Metab Cardiovasc Dis. 2006; 16(2):91-9. DOI: 10.1016/j.numecd.2005.04.004. View

Fito M, Guxens M, Corella D, Saez G, Estruch R, de la Torre R . Effect of a traditional Mediterranean diet on lipoprotein oxidation: a randomized controlled trial. Arch Intern Med. 2007; 167(11):1195-1203. DOI: 10.1001/archinte.167.11.1195. View

Aviram M, Fuhrman B . Polyphenolic flavonoids inhibit macrophage-mediated oxidation of LDL and attenuate atherogenesis. Atherosclerosis. 1998; 137 Suppl:S45-50. DOI: 10.1016/s0021-9150(97)00306-7. View

10.

Traber M, KAYDEN H . Preferential incorporation of alpha-tocopherol vs gamma-tocopherol in human lipoproteins. Am J Clin Nutr. 1989; 49(3):517-26. DOI: 10.1093/ajcn/49.3.517. View

11.

Wactawski-Wende J, Schisterman E, Hovey K, Howards P, Browne R, Hediger M . BioCycle study: design of the longitudinal study of the oxidative stress and hormone variation during the menstrual cycle. Paediatr Perinat Epidemiol. 2009; 23(2):171-84. PMC: 2722955. DOI: 10.1111/j.1365-3016.2008.00985.x. View

12.

Fossati P, PRENCIPE L . Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin Chem. 1982; 28(10):2077-80. View

13.

Janero D . Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic Biol Med. 1990; 9(6):515-40. DOI: 10.1016/0891-5849(90)90131-2. View

14.

Milne G, Sanchez S, Musiek E, Morrow J . Quantification of F2-isoprostanes as a biomarker of oxidative stress. Nat Protoc. 2007; 2(1):221-6. DOI: 10.1038/nprot.2006.375. View

15.

Trichopoulou A, Costacou T, Bamia C, Trichopoulos D . Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med. 2003; 348(26):2599-608. DOI: 10.1056/NEJMoa025039. View

16.

Bjelakovic G, Nikolova D, Gluud L, Simonetti R, Gluud C . Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev. 2008; (2):CD007176. DOI: 10.1002/14651858.CD007176. View

17.

Browne R, Bloom M, Schisterman E, Hovey K, Trevisan M, Wu C . Analytical and biological variation of biomarkers of oxidative stress during the menstrual cycle. Biomarkers. 2008; 13(2):160-83. PMC: 2504010. DOI: 10.1080/13547500701775563. View

18.

Munteanu A, Zingg J, Azzi A . Anti-atherosclerotic effects of vitamin E--myth or reality?. J Cell Mol Med. 2004; 8(1):59-76. PMC: 6740318. DOI: 10.1111/j.1582-4934.2004.tb00260.x. View

19.

Browne R, Bloom M, Schisterman E, Wactawski-Wende J, Hovey K, Trevisan M . Analytical and biological variation of F2-isoprostanes during the menstrual cycle. Clin Chem. 2009; 55(6):1245-7. PMC: 2749470. DOI: 10.1373/clinchem.2008.122101. View

20.

Carr A, Zhu B, Frei B . Potential antiatherogenic mechanisms of ascorbate (vitamin C) and alpha-tocopherol (vitamin E). Circ Res. 2000; 87(5):349-54. DOI: 10.1161/01.res.87.5.349. View