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Sorting It out in Endosomes: an Emerging Concept in Renal Epithelial Cell Transport Regulation

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Specialty Physiology
Date 2010 Oct 14
PMID 20940433
Citations 15
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Abstract

Ion and water transport by the kidney is continually adjusted in response to physiological cues. Selective endocytosis and endosomal trafficking of ion transporters are increasingly appreciated as mechanisms to acutely modulate renal function. Here, we discuss emerging paradigms in this new area of investigation.

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References
1.
McCormick P, Dumaresq-Doiron K, Pluviose A, Pichette V, Tosato G, Lefrancois S . Palmitoylation controls recycling in lysosomal sorting and trafficking. Traffic. 2008; 9(11):1984-97. PMC: 3500849. DOI: 10.1111/j.1600-0854.2008.00814.x. View

2.
van der Sluijs P, Hull M, Webster P, MALE P, Goud B, Mellman I . The small GTP-binding protein rab4 controls an early sorting event on the endocytic pathway. Cell. 1992; 70(5):729-40. DOI: 10.1016/0092-8674(92)90307-x. View

3.
Henry L, Sheff D . Rab8 regulates basolateral secretory, but not recycling, traffic at the recycling endosome. Mol Biol Cell. 2008; 19(5):2059-68. PMC: 2366880. DOI: 10.1091/mbc.e07-09-0902. View

4.
Yang L, Maunsbach A, Leong P, McDonough A . Differential traffic of proximal tubule Na+ transporters during hypertension or PTH: NHE3 to base of microvilli vs. NaPi2 to endosomes. Am J Physiol Renal Physiol. 2004; 287(5):F896-906. DOI: 10.1152/ajprenal.00160.2004. View

5.
Fang L, Garuti R, Kim B, Wade J, Welling P . The ARH adaptor protein regulates endocytosis of the ROMK potassium secretory channel in mouse kidney. J Clin Invest. 2009; 119(11):3278-89. PMC: 2769171. DOI: 10.1172/JCI37950. View