Capturing the Essence of Organic Synthesis: from Bioactive Natural Products to Designed Molecules in Today's Medicine

Overview

Journal J Org Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2010 Oct 13

PMID 20936876

Citations 6

Authors

Arun K Ghosh

Affiliations

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Abstract

In this Perspective, I outline my group's research involving the chemical syntheses of medicinally important natural products, exploration of their bioactivity, and the development of new asymmetric carbon-carbon bond-forming reactions. This paper also highlights our approach to molecular design and synthesis of conceptually novel inhibitors against target proteins involved in the pathogenesis of human diseases, including AIDS and Alzheimer's disease.

Citing Articles

Beyond darunavir: recent development of next generation HIV-1 protease inhibitors to combat drug resistance.

Ghosh A, Weber I, Mitsuya H Chem Commun (Camb). 2022; 58(84):11762-11782.

PMID: 36200462 PMC: 10942761. DOI: 10.1039/d2cc04541a.

Novel 2-Aryloxazoline Compounds Exhibit an Inhibitory Effect on spp., Including Antifungal-Resistant Isolates.

Argomedo L, Barroso V, Barreiro C, Darbem M, Ishida K, Stefani H ACS Med Chem Lett. 2020; 11(12):2470-2475.

PMID: 33335669 PMC: 7734819. DOI: 10.1021/acsmedchemlett.0c00449.

Nature Inspired Molecular Design: Stereoselective Synthesis of Bicyclic and Polycyclic Ethers for Potent HIV-1 Protease Inhibitors.

Ghosh A, Brindisi M Asian J Org Chem. 2019; 7(8):1448-1466.

PMID: 31595212 PMC: 6781882. DOI: 10.1002/ajoc.201800255.

Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.

Ghosh A, Brindisi M, Nyalapatla P, Takayama J, Ella-Menye J, Yashchuk S Bioorg Med Chem. 2017; 25(19):5114-5127.

PMID: 28434781 PMC: 5617771. DOI: 10.1016/j.bmc.2017.04.005.

Addressing Structural Flexibility at the A-Ring on Salvinorin A: Discovery of a Potent Kappa-Opioid Agonist with Enhanced Metabolic Stability.

Sherwood A, Crowley R, Paton K, Biggerstaff A, Neuenswander B, Day V J Med Chem. 2017; 60(9):3866-3878.

PMID: 28376298 PMC: 5546011. DOI: 10.1021/acs.jmedchem.7b00148.

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