Assessment of Tissue Perfusion by Contrast-enhanced Ultrasound

Overview

Journal Eur Radiol

Specialty Radiology

Date 2010 Oct 8

PMID 20927527

Citations 37

Authors

Emilio Quaia

Affiliations

Soon will be listed here.

Abstract

Contrast-enhanced ultrasound (CEUS) with microbubble contrast agents is a new imaging technique for quantifying tissue perfusion. CEUS presents several advantages over other imaging techniques in assessing tissue perfusion, including the use of microbubbles as blood-pool agents, portability, availability and absence of exposure to radiation or nuclear tracers. Dedicated software packages are necessary to quantify the echo-signal intensity and allow the calculation of the degree of tissue contrast enhancement based on the accurate distinction between microbubble backscatter signals and native tissue background. The measurement of organ transit time after microbubble injection and the analysis of tissue reperfusion kinetics represent the two fundamental methods for the assessment of tissue perfusion by CEUS. Transit time measurement has been shown to be feasible and has started to become accepted as a clinical tool, especially in the liver. The loudness of audio signals from spectral Doppler analysis is used to generate time-intensity curves to follow the wash-in and wash-out of the microbubble bolus. Tissue perfusion may be quantified also by analysing the replenishment kinetics of the volume of microbubbles after their destruction in the imaged slice. This allows to obtain semiquantitative parameters related to local tissue perfusion, especially in the heart, brain, and kidneys.

Citing Articles

Assessing Therapeutic Nanoparticle Accumulation in Tumors Using Nanobubble-Based Contrast-Enhanced Ultrasound Imaging.

Cooley M, Wegierak D, Perera R, Abenojar E, Nittayacharn P, Berg F ACS Nano. 2024; 18(48):33181-33196.

PMID: 39566912 PMC: 11619768. DOI: 10.1021/acsnano.4c11805.

Comparison of contrast-enhanced ultrasound imaging (CEUS) and super-resolution ultrasound (SRU) for the quantification of ischaemia flow redistribution: a theoretical study.

Arthur L, Voulgaridou V, Butler M, Papageorgiou G, Lu W, McDougall S Phys Med Biol. 2024; 69(23).

PMID: 39536710 PMC: 11583374. DOI: 10.1088/1361-6560/ad9231.

Nanobubble Contrast Enhanced Ultrasound Imaging: A Review.

Wegierak D, Nittayacharn P, Cooley M, Berg F, Kosmides T, Durig D Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2024; 16(6):e2007.

PMID: 39511794 PMC: 11567054. DOI: 10.1002/wnan.2007.

The application value of two-dimensional ultrasound combined with contrast-enhanced ultrasound in the differential diagnosis of benign, borderline, and malignant ovarian epithelial tumors.

Wang R, Liu H, Tang J, Geng J J Ovarian Res. 2024; 17(1):191.

PMID: 39342318 PMC: 11438069. DOI: 10.1186/s13048-024-01514-0.

Prediction of renal recovery following sepsis-associated acute kidney injury requiring renal replacement therapy using contrast-enhanced ultrasonography.

Shin J, Hwang J, Park S, Kim S Kidney Res Clin Pract. 2023; 42(4):473-486.

PMID: 37551127 PMC: 10407630. DOI: 10.23876/j.krcp.22.086.

References

McCarville M, Streck C, Dickson P, Li C, Nathwani A, Davidoff A . Angiogenesis inhibitors in a murine neuroblastoma model: quantitative assessment of intratumoral blood flow with contrast-enhanced gray-scale US. Radiology. 2006; 240(1):73-81. DOI: 10.1148/radiol.2401050709. View

Wei K, Jayaweera A, Firoozan S, Linka A, Skyba D, Kaul S . Basis for detection of stenosis using venous administration of microbubbles during myocardial contrast echocardiography: bolus or continuous infusion?. J Am Coll Cardiol. 1998; 32(1):252-60. DOI: 10.1016/s0735-1097(98)00212-5. View

Piscaglia F, Bolondi L . The safety of Sonovue in abdominal applications: retrospective analysis of 23188 investigations. Ultrasound Med Biol. 2006; 32(9):1369-75. DOI: 10.1016/j.ultrasmedbio.2006.05.031. View

Daghini E, Primak A, Chade A, Krier J, Zhu X, Ritman E . Assessment of renal hemodynamics and function in pigs with 64-section multidetector CT: comparison with electron-beam CT. Radiology. 2007; 243(2):405-12. DOI: 10.1148/radiol.2432060655. View

Wei K, Tong K, Belcik T, Rafter P, Ragosta M, Wang X . Detection of coronary stenoses at rest with myocardial contrast echocardiography. Circulation. 2005; 112(8):1154-60. DOI: 10.1161/CIRCULATIONAHA.104.513887. View

Blomley M, Albrecht T, Cosgrove D, Jayaram V, Eckersley R, Patel N . Liver vascular transit time analyzed with dynamic hepatic venography with bolus injections of an US contrast agent: early experience in seven patients with metastases. Radiology. 1998; 209(3):862-6. DOI: 10.1148/radiology.209.3.9844688. View

Albrecht T, Blomley M, Cosgrove D, Taylor-Robinson S, Jayaram V, Eckersley R . Non-invasive diagnosis of hepatic cirrhosis by transit-time analysis of an ultrasound contrast agent. Lancet. 1999; 353(9164):1579-83. DOI: 10.1016/S0140-6736(98)06373-9. View

Quaia E . Microbubble ultrasound contrast agents: an update. Eur Radiol. 2007; 17(8):1995-2008. DOI: 10.1007/s00330-007-0623-0. View

Taylor G, Barnewolt C, Claudon M, Dunning P . Depiction of renal perfusion defects with contrast-enhanced harmonic sonography in a porcine model. AJR Am J Roentgenol. 1999; 173(3):757-60. DOI: 10.2214/ajr.173.3.10470918. View

10.

Gasparini C, Bertolotto M, Croce S, Perrone R, Quaia E, Tiribelli C . Evaluation of liver parenchymal blood flow with contrast-enhanced US: preliminary results in healthy and cirrhotic patients. Acad Radiol. 2003; 10(8):869-76. DOI: 10.1016/s1076-6332(03)00003-5. View

11.

Correas J, Claudon M, Tranquart F, Helenon O . [Contrast-enhanced ultrasonography: renal applications]. J Radiol. 2004; 84(12 Pt 2):2041-54. View

12.

Krix M, Kiessling F, Farhan N, Schmidt K, Hoffend J, Delorme S . A multivessel model describing replenishment kinetics of ultrasound contrast agent for quantification of tissue perfusion. Ultrasound Med Biol. 2003; 29(10):1421-30. DOI: 10.1016/s0301-5629(03)01033-0. View

13.

Kihm L, Hinkel U, Michael K, Sommerer C, Seckinger J, Morath C . Contrast enhanced sonography shows superior microvascular renal allograft perfusion in patients switched from cyclosporine A to everolimus. Transplantation. 2009; 88(2):261-5. DOI: 10.1097/TP.0b013e3181ac8cdd. View

14.

Wei K, Jayaweera A, Firoozan S, Linka A, Skyba D, Kaul S . Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion. Circulation. 1998; 97(5):473-83. DOI: 10.1161/01.cir.97.5.473. View

15.

Yanagisawa K, Moriyasu F, Miyahara T, Yuki M, Iijima H . Phagocytosis of ultrasound contrast agent microbubbles by Kupffer cells. Ultrasound Med Biol. 2007; 33(2):318-25. DOI: 10.1016/j.ultrasmedbio.2006.08.008. View

16.

Paltiel H, Kalish L, Susaeta R, Frauscher F, OKane P, Freitas-Filho L . Pulse-inversion US imaging of testicular ischemia: quantitative and qualitative analyses in a rabbit model. Radiology. 2006; 239(3):718-29. DOI: 10.1148/radiol.2393050210. View

17.

Yankeelov T, Niermann K, Huamani J, Kim D, Quarles C, Fleischer A . Correlation between estimates of tumor perfusion from microbubble contrast-enhanced sonography and dynamic contrast-enhanced magnetic resonance imaging. J Ultrasound Med. 2006; 25(4):487-97. DOI: 10.7863/jum.2006.25.4.487. View

18.

Potdevin T, Fowlkes J, Moskalik A, Carson P . Refill model of rabbit kidney vasculature. Ultrasound Med Biol. 2006; 32(9):1331-8. DOI: 10.1016/j.ultrasmedbio.2006.05.025. View

19.

Wiesmann M, Meyer K, Albers T, Seidel G . Parametric perfusion imaging with contrast-enhanced ultrasound in acute ischemic stroke. Stroke. 2004; 35(2):508-13. DOI: 10.1161/01.STR.0000114877.58809.3D. View

20.

Winehouse J, Douek M, Holz K, Madjar H, Gillams A, Lees W . Contrast-enhanced colour Doppler ultrasonography in suspected breast cancer recurrence. Br J Surg. 1999; 86(9):1198-201. DOI: 10.1046/j.1365-2168.1999.01163.x. View