Effects of Triclocarban on Intact Immature Male Rat: Augmentation of Androgen Action

Overview

Journal Reprod Sci

Publisher Springer

Specialty Reproductive Medicine

Date 2010 Oct 5

PMID 20889956

Citations 14

Authors

Antoni J Duleba

Mohamed I Ahmed

Meng Sun

Allen C Gao

Jesus Villanueva

Alan J Conley

Judith L Turgeon

Kurt Benirschke

Nancy A Gee

Jiangang Chen

Peter G Green

Bill L Lasley

Affiliations

Soon will be listed here.

Abstract

Triclocarban (TCC; 3,4,4'-trichlorocarbanilide) is an antimicrobial agent used widely in various personal hygiene products including soaps. Recently, TCC has been shown to enhance testosterone-induced effects in vitro and to enlarge accessory sex organs in castrated male rats. This study was designed to evaluate the effects of TCC on intact age-matched male rats and on human prostate LNCaP and C4-2B cells. Seven-week-old male Sprague-Dawley rats received either a normal diet or a diet supplemented with TCC (0.25% in diet) for 10 days. Triclocarban induced hyperplasia of accessory sex organs in the absence of significant qualitative histological changes. Serum luteinizing hormone (LH) and testosterone were not significantly altered by TCC treatment. In prostate cancer-derived LNCaP and C4-2B cells, TCC potentiated androgen actions via androgen receptor-dependent actions. In conclusion, TCC significantly affects intact male reproductive organs and potentiates androgen effects in prostate cancer cells.

Citing Articles

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The Different Facets of Triclocarban: A Review.

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Triclocarban exposure exaggerates colitis and colon tumorigenesis: roles of gut microbiota involved.

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Structure and specificity of several triclocarban-binding single domain camelid antibody fragments.

Tabares-da Rosa S, Wogulis L, Wogulis M, Gonzalez-Sapienza G, Wilson D J Mol Recognit. 2018; 32(1):e2755.

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