Individual Differences in Subconscious Motor Control Predicted by GABA Concentration in SMA

Overview

Journal Curr Biol

Publisher Cell Press

Specialty Biology

Date 2010 Oct 5

PMID 20888227

Citations 87

Authors

Frederic Boy

C John Evans

Richard A E Edden

Krish D Singh

Masud Husain

Petroc Sumner

Affiliations

Soon will be listed here.

Abstract

Subliminal visual stimuli affect motor planning, but the size of such effects differs greatly between individuals. Here, we investigated whether such variation may be related to neurochemical differences between people. Cortical responsiveness is expected to be lower under the influence of more of the main inhibitory neurotransmitter, GABA. Thus, we hypothesized that, if an individual has more GABA in the supplementary motor area (SMA)--a region previously associated with automatic motor control--this would result in smaller subliminal effects. We measured the reversed masked prime--or negative compatibility--effect, and found that it correlated strongly with GABA concentration, measured with magnetic resonance spectroscopy. This occurred specifically in the SMA region, and not in other regions from which spectroscopy measurements were taken. We replicated these results in an independent cohort: more GABA in the SMA region is reliably associated with smaller effect size. These findings suggest that, across individuals, the responsiveness of subconscious motor mechanisms is related to GABA concentration in the SMA.

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References

Sumner P, Nachev P, Morris P, Peters A, Jackson S, Kennard C . Human medial frontal cortex mediates unconscious inhibition of voluntary action. Neuron. 2007; 54(5):697-711. PMC: 1890004. DOI: 10.1016/j.neuron.2007.05.016. View

Sumner P . Mask-induced priming and the negative compatibility effect. Exp Psychol. 2008; 55(2):133-41. DOI: 10.1027/1618-3169.55.2.133. View

Pouget P, Wattiez N, Rivaud-Pechoux S, Gaymard B . A fragile balance: perturbation of GABA mediated circuit in prefrontal cortex generates high intraindividual performance variability. PLoS One. 2009; 4(4):e5208. PMC: 2668174. DOI: 10.1371/journal.pone.0005208. View

Verbruggen F, Logan G, Stevens M . STOP-IT: Windows executable software for the stop-signal paradigm. Behav Res Methods. 2008; 40(2):479-83. DOI: 10.3758/brm.40.2.479. View

Kaiser L, Young K, Meyerhoff D, Mueller S, Matson G . A detailed analysis of localized J-difference GABA editing: theoretical and experimental study at 4 T. NMR Biomed. 2007; 21(1):22-32. DOI: 10.1002/nbm.1150. View

Egner T, Delano M, Hirsch J . Separate conflict-specific cognitive control mechanisms in the human brain. Neuroimage. 2007; 35(2):940-8. DOI: 10.1016/j.neuroimage.2006.11.061. View

Bhagwagar Z, Wylezinska M, Jezzard P, Evans J, Ashworth F, Sule A . Reduction in occipital cortex gamma-aminobutyric acid concentrations in medication-free recovered unipolar depressed and bipolar subjects. Biol Psychiatry. 2007; 61(6):806-12. DOI: 10.1016/j.biopsych.2006.08.048. View

Logan G, Cowan W, Davis K . On the ability to inhibit simple and choice reaction time responses: a model and a method. J Exp Psychol Hum Percept Perform. 1984; 10(2):276-91. DOI: 10.1037//0096-1523.10.2.276. View

Aron A . The neural basis of inhibition in cognitive control. Neuroscientist. 2007; 13(3):214-28. DOI: 10.1177/1073858407299288. View

10.

Boy F, Husain M, Sumner P . Unconscious inhibition separates two forms of cognitive control. Proc Natl Acad Sci U S A. 2010; 107(24):11134-9. PMC: 2890757. DOI: 10.1073/pnas.1001925107. View

11.

Hermens F, Sumner P, Walker R . Inhibition of masked primes as revealed by saccade curvature. Vision Res. 2009; 50(1):46-56. DOI: 10.1016/j.visres.2009.10.008. View

12.

Kalueff A, Nutt D . Role of GABA in anxiety and depression. Depress Anxiety. 2006; 24(7):495-517. DOI: 10.1002/da.20262. View

13.

Yoon J, Maddock R, Rokem A, Silver M, Minzenberg M, Ragland J . GABA concentration is reduced in visual cortex in schizophrenia and correlates with orientation-specific surround suppression. J Neurosci. 2010; 30(10):3777-81. PMC: 2846788. DOI: 10.1523/JNEUROSCI.6158-09.2010. View

14.

Sanacora G, MASON G, Rothman D, Behar K, Hyder F, Petroff O . Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy. Arch Gen Psychiatry. 1999; 56(11):1043-7. DOI: 10.1001/archpsyc.56.11.1043. View

15.

Floyer-Lea A, Wylezinska M, Kincses T, Matthews P . Rapid modulation of GABA concentration in human sensorimotor cortex during motor learning. J Neurophysiol. 2005; 95(3):1639-44. DOI: 10.1152/jn.00346.2005. View

16.

Hasler G, Neumeister A, van der Veen J, Tumonis T, Bain E, Shen J . Normal prefrontal gamma-aminobutyric acid levels in remitted depressed subjects determined by proton magnetic resonance spectroscopy. Biol Psychiatry. 2005; 58(12):969-73. DOI: 10.1016/j.biopsych.2005.05.017. View

17.

Choi C, Bhardwaj P, Kalra S, Casault C, Yasmin U, Allen P . Measurement of GABA and contaminants in gray and white matter in human brain in vivo. Magn Reson Med. 2007; 58(1):27-33. DOI: 10.1002/mrm.21275. View

18.

Nakamura K, Sakai K, Hikosaka O . Effects of local inactivation of monkey medial frontal cortex in learning of sequential procedures. J Neurophysiol. 1999; 82(2):1063-8. DOI: 10.1152/jn.1999.82.2.1063. View

19.

Petty F, Kramer G, Dunnam D, Rush A . Plasma GABA in mood disorders. Psychopharmacol Bull. 1990; 26(2):157-61. View

20.

Evans C, McGonigle D, Edden R . Diurnal stability of gamma-aminobutyric acid concentration in visual and sensorimotor cortex. J Magn Reson Imaging. 2009; 31(1):204-9. DOI: 10.1002/jmri.21996. View