Dynamics of Inflammatory Markers in Post-acute Stroke Patients Undergoing Rehabilitation

Overview

Journal Inflammation

Specialties Allergy & Immunology
Pathology

Date 2010 Oct 1

PMID 20882328

Citations 6

Authors

Bogdan Nicolae Manolescu

Mihai Berteanu

Luminita Dumitru

Horatiu Dinu

Alina Iliescu

Ileana Cornelia Farcasanu

Eliza Oprea

Suzana Vladoiu

Oana Popa

Olga Ianas

Affiliations

Soon will be listed here.

Abstract

Stroke is a pathological condition associated with an enhanced inflammatory response that has a multifactorial etiology. We evaluated the dynamic of plasma concentrations of IL-1α, IL-6, IL-8, TNF-α, soluble form of intercellular adhesion molecule 1, and lipoprotein (a) [Lp(a)] during the rehabilitation of post-acute stroke patients (n = 20), in parallel with control subjects (n = 24). Stroke patients had significantly increased concentrations of IL-6, TNF-α, and Lp(a) when compared to healthy controls. It was found that the changes in the IL-6, IL-8, and TNF-α concentrations associated with the pathological condition were statistically significant (χ2 = 4.81, p = 0.028, χ2 = 10.40, p = 0.005 and χ2 = 6.73, p = 0.034, respectively). The decrease of Lp(a) during the rehabilitation had statistical significance (p = 0.043), while the decrease of IL-1α had marginal significance (p = 0.071). IL-1α, TNF-α, and Lp(a) concentrations were significantly negatively correlated with the Barthel index values, suggesting that the decrease of these inflammatory markers was beneficial for patients' recovery.

Citing Articles

Association between interleukin-6 levels and stroke: a systematic review and meta-analysis.

Huang X, Zhang M, Wang J, Hu F J Int Med Res. 2024; 52(9):3000605241274626.

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Improving physical movement during stroke rehabilitation: investigating associations between sleep measured by wearable actigraphy technology, fatigue, and key biomarkers.

Smith M, Pellegrini M, Major B, Graco M, Porter S, Kramer S J Neuroeng Rehabil. 2024; 21(1):84.

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Investigating the Potential Mechanisms and Therapeutic Targets of Inflammatory Cytokines in Post-stroke Depression.

Zhang Y, Yang Y, Li H, Feng Q, Ge W, Xu X Mol Neurobiol. 2023; 61(1):132-147.

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State of the science in inflammation and stroke recovery: A systematic review.

Couch C, Mallah K, Borucki D, Bonilha H, Tomlinson S Ann Phys Rehabil Med. 2021; 65(2):101546.

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Plasma Biomarkers as Potential Predictors of Functional Dependence in Daily Life Activities after Ischemic Stroke: A Single Center Study.

Hutanu A, Iancu M, Maier S, Balasa R, Dobreanu M Ann Indian Acad Neurol. 2020; 23(4):496-503.

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References

Kettritz R, Gaido M, Haller H, Luft F, Jennette C, Falk R . Interleukin-8 delays spontaneous and tumor necrosis factor-alpha-mediated apoptosis of human neutrophils. Kidney Int. 1998; 53(1):84-91. DOI: 10.1046/j.1523-1755.1998.00741.x. View

Dechanet J, Grosset C, Taupin J, Merville P, Banchereau J, Ripoche J . CD40 ligand stimulates proinflammatory cytokine production by human endothelial cells. J Immunol. 1998; 159(11):5640-7. View

Slemmer J, Shacka J, Sweeney M, Weber J . Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging. Curr Med Chem. 2008; 15(4):404-14. DOI: 10.2174/092986708783497337. View

Woodfin A, Voisin M, Nourshargh S . Recent developments and complexities in neutrophil transmigration. Curr Opin Hematol. 2009; 17(1):9-17. PMC: 2882030. DOI: 10.1097/MOH.0b013e3283333930. View

Vila N, Castillo J, Davalos A, Chamorro A . Proinflammatory cytokines and early neurological worsening in ischemic stroke. Stroke. 2000; 31(10):2325-9. DOI: 10.1161/01.str.31.10.2325. View

Jones G, Deng M, Hammond-Tooke G, McCormick S, van Rij A . Increased plasma lipoprotein(a) found in large-artery atherosclerotic, but not small-artery occlusive, stroke. Clin Chem. 2009; 55(10):1888-90. DOI: 10.1373/clinchem.2009.126771. View

Jian Liu K, Rosenberg G . Matrix metalloproteinases and free radicals in cerebral ischemia. Free Radic Biol Med. 2005; 39(1):71-80. DOI: 10.1016/j.freeradbiomed.2005.03.033. View

Song Y, Kim M, Kim H, Jung B, Yang J, Narasimhan P . Oxidative stress increases phosphorylation of IkappaB kinase-alpha by enhancing NF-kappaB-inducing kinase after transient focal cerebral ischemia. J Cereb Blood Flow Metab. 2010; 30(7):1265-74. PMC: 2888847. DOI: 10.1038/jcbfm.2010.6. View

Nilupul Perera M, Ma H, Arakawa S, Howells D, Markus R, Rowe C . Inflammation following stroke. J Clin Neurosci. 2006; 13(1):1-8. DOI: 10.1016/j.jocn.2005.07.005. View

10.

De Simoni M, Milia P, Barba M, De Luigi A, Parnetti L, Gallai V . The inflammatory response in cerebral ischemia: focus on cytokines in stroke patients. Clin Exp Hypertens. 2002; 24(7-8):535-42. DOI: 10.1081/ceh-120015330. View

11.

Tong Y, Geng Y, Xu J, Wang Z, Zhang Y, Lin L . The role of functional polymorphisms of the TNF-alpha gene promoter in the risk of ischemic stroke in Chinese Han and Uyghur populations: Two case-control studies. Clin Chim Acta. 2010; 411(17-18):1291-5. DOI: 10.1016/j.cca.2010.05.007. View

12.

Lakhan S, Kirchgessner A, Hofer M . Inflammatory mechanisms in ischemic stroke: therapeutic approaches. J Transl Med. 2009; 7:97. PMC: 2780998. DOI: 10.1186/1479-5876-7-97. View

13.

Kostulas N, Pelidou S, Kivisakk P, Kostulas V, Link H . Increased IL-1beta, IL-8, and IL-17 mRNA expression in blood mononuclear cells observed in a prospective ischemic stroke study. Stroke. 1999; 30(10):2174-9. DOI: 10.1161/01.str.30.10.2174. View

14.

MAHONEY F, BARTHEL D . FUNCTIONAL EVALUATION: THE BARTHEL INDEX. Md State Med J. 1965; 14:61-5. View

15.

Elkind M, Cheng J, Rundek T, Boden-Albala B, Sacco R . Leukocyte count predicts outcome after ischemic stroke: the Northern Manhattan Stroke Study. J Stroke Cerebrovasc Dis. 2007; 13(5):220-7. DOI: 10.1016/j.jstrokecerebrovasdis.2004.07.004. View

16.

Wong C, Crack P . Modulation of neuro-inflammation and vascular response by oxidative stress following cerebral ischemia-reperfusion injury. Curr Med Chem. 2008; 15(1):1-14. DOI: 10.2174/092986708783330665. View

17.

Tarkowski E, Rosengren L, Blomstrand C, Wikkelso C, Jensen C, Ekholm S . Early intrathecal production of interleukin-6 predicts the size of brain lesion in stroke. Stroke. 1995; 26(8):1393-8. DOI: 10.1161/01.str.26.8.1393. View

18.

Jin R, Yang G, Li G . Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J Leukoc Biol. 2010; 87(5):779-89. PMC: 2858674. DOI: 10.1189/jlb.1109766. View

19.

Acalovschi D, Wiest T, Hartmann M, Farahmi M, Mansmann U, Auffarth G . Multiple levels of regulation of the interleukin-6 system in stroke. Stroke. 2003; 34(8):1864-9. DOI: 10.1161/01.STR.0000079815.38626.44. View

20.

Erqou S, Kaptoge S, Perry P, Di Angelantonio E, Thompson A, White I . Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality. JAMA. 2009; 302(4):412-23. PMC: 3272390. DOI: 10.1001/jama.2009.1063. View