Sevoflurane Postconditioning Ameliorates Oxygen-glucose Deprivation-reperfusion Injury in the Rat Hippocampus

Overview

Journal CNS Neurosci Ther

Specialties Neurology
Pharmacology

Date 2010 Sep 30

PMID 20875045

Citations 10

Authors

Sheng Peng

Pramood Kalikiri

George Mychaskiw 2nd

Dengxin Zhang

Yan Zhang

Gong-Jian Liu

Guang-Lei Wang

Zhi-yun Shen

Affiliations

Soon will be listed here.

Abstract

Introduction: Sevoflurane is well known to exert a neuroprotective effect through anesthetic preconditioning. However, its effects on postconditioning, a neuroprotective phenomenon following an insult, have not been well studied.

Aims: In this study, we examined the ability of sevoflurane to induce postconditioning in rat hippocampal slices, in vitro.

Results: 2%, 4%, and 6% sevoflurane reduced neurophysiologic and morphologic neuronal injury following oxygen-glucose deprivation (OGD) and reperfusion. The quantity of damaged neurons was significantly reduced on immunofluorescence staining; excitatory amino acids (Asp, Glu) increased and inhibitory amino acids (GABA) decreased significantly. The effect was concentration-dependent.

Conclusion: Postconditioning with sevoflurane reduces neuronal damage after OGD-reperfusion injury in the CA1 area of rat hippocampus, in vitro.

Citing Articles

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