5-HT₁A Receptor Binding is Increased After Recovery from Bulimia Nervosa Compared to Control Women and is Associated with Behavioral Inhibition in Both Groups

Overview

Journal Int J Eat Disord

Publisher Wiley

Specialty Social Sciences

Date 2010 Sep 28

PMID 20872754

Citations 13

Authors

Ursula F Bailer

Cinnamon S Bloss

Guido K Frank

Julie C Price

Carolyn C Meltzer

Chester A Mathis

Mark A Geyer

Angela Wagner

Carl R Becker

Nicholas J Schork

Walter H Kaye

Affiliations

Soon will be listed here.

Abstract

Objective: Because altered serotonin (5-HT) function appears to persist after recovery from bulimia nervosa (RBN), we investigated the 5-HT(1A) receptor, which could contribute to regulation of appetite, mood, impulse control, or the response to antidepressants.

Method: Thirteen RBN individuals were compared to 21 healthy control women (CW) using positron emission tomography and [carbonyl-(11)C]WAY100635 ([(11)C]WAY).

Results: RBN had a 23-34% elevation of [(11)C]WAY binding potential (BP)(P) in subgenual cingulate, mesial temporal, and parietal regions after adjustments for multiple comparisons. For CW, [(11)C]WAY BP(P) was related negatively to novelty seeking, whereas for RBN, [(11)C]WAY BP(P) was related positively to harm avoidance and negatively related to sensation seeking.

Discussion: Alterations of 5-HT(1A) receptor function may provide new insight into efficacy of 5-HT medication in BN, as well as symptoms such as the ability to inhibit or self-control the expression of behaviors related to stimulus seeking, aggression, and impulsivity.

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