The Impact of the Extracellular Matrix on Inflammation

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2010 Sep 25

PMID 20865019

Citations 424

Authors

Lydia Sorokin

Affiliations

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Abstract

The advent of in situ immunology and intravital analyses of leukocyte movement in tissues has drawn attention to the previously neglected extracellular matrix (ECM) and its role in modulating immune cell behaviour in inflamed tissues. The ECM exists in different biochemical and structural forms; both their individual components and three-dimensional ultrastructure impart specific signals to cells that modulate basic functions that are important for the early steps in inflammation, such as immune cell migration into inflamed tissues and immune cell differentiation. In chronically inflamed tissues, aberrant ECM expression and fragments of the ECM that are derived from tissue-remodelling processes can influence immune cell activation and survival, thereby actively contributing to immune responses at these sites.

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References

Hayashida K, Parks W, Park P . Syndecan-1 shedding facilitates the resolution of neutrophilic inflammation by removing sequestered CXC chemokines. Blood. 2009; 114(14):3033-43. PMC: 2756208. DOI: 10.1182/blood-2009-02-204966. View

Friedl P, Wolf K . Proteolytic and non-proteolytic migration of tumour cells and leucocytes. Biochem Soc Symp. 2003; (70):277-85. DOI: 10.1042/bss0700277. View

McQuibban G, Butler G, Gong J, Bendall L, Power C, Clark-Lewis I . Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1. J Biol Chem. 2001; 276(47):43503-8. DOI: 10.1074/jbc.M107736200. View

Li S, Harrison D, Carbonetto S, Fassler R, Smyth N, Edgar D . Matrix assembly, regulation, and survival functions of laminin and its receptors in embryonic stem cell differentiation. J Cell Biol. 2002; 157(7):1279-90. PMC: 2173546. DOI: 10.1083/jcb.200203073. View

Huber A, Weiss S . Disruption of the subendothelial basement membrane during neutrophil diapedesis in an in vitro construct of a blood vessel wall. J Clin Invest. 1989; 83(4):1122-36. PMC: 303798. DOI: 10.1172/JCI113992. View

Engelhardt B, Wolburg H . Mini-review: Transendothelial migration of leukocytes: through the front door or around the side of the house?. Eur J Immunol. 2004; 34(11):2955-63. DOI: 10.1002/eji.200425327. View

Sasaki T, Larsson H, Tisi D, Claesson-Welsh L, Hohenester E, Timpl R . Endostatins derived from collagens XV and XVIII differ in structural and binding properties, tissue distribution and anti-angiogenic activity. J Mol Biol. 2000; 301(5):1179-90. DOI: 10.1006/jmbi.2000.3996. View

Pender M, Nguyen K, McCombe P, KERR J . Apoptosis in the nervous system in experimental allergic encephalomyelitis. J Neurol Sci. 1991; 104(1):81-7. DOI: 10.1016/0022-510x(91)90219-w. View

Burns A, Smith C, Walker D . Unique structural features that influence neutrophil emigration into the lung. Physiol Rev. 2003; 83(2):309-36. DOI: 10.1152/physrev.00023.2002. View

10.

McKEE C, Penno M, Cowman M, Burdick M, Strieter R, Bao C . Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44. J Clin Invest. 1996; 98(10):2403-13. PMC: 507693. DOI: 10.1172/JCI119054. View

11.

Senior R, Griffin G, Mecham R . Chemotactic activity of elastin-derived peptides. J Clin Invest. 1980; 66(4):859-62. PMC: 371663. DOI: 10.1172/JCI109926. View

12.

Wekerle H . Lessons from multiple sclerosis: models, concepts, observations. Ann Rheum Dis. 2008; 67 Suppl 3:iii56-60. DOI: 10.1136/ard.2008.098020. View

13.

McKee K, Harrison D, Capizzi S, Yurchenco P . Role of laminin terminal globular domains in basement membrane assembly. J Biol Chem. 2007; 282(29):21437-47. DOI: 10.1074/jbc.M702963200. View

14.

Xu G, Nie H, Li N, Zheng W, Zhang D, Feng G . Role of osteopontin in amplification and perpetuation of rheumatoid synovitis. J Clin Invest. 2005; 115(4):1060-7. PMC: 1059449. DOI: 10.1172/JCI23273. View

15.

Ohashi K, Tung D, Wilson J, ZWEIFACH B, Schmid-Schonbein G . Transvascular and interstitial migration of neutrophils in rat mesentery. Microcirculation. 1996; 3(2):199-210. DOI: 10.3109/10739689609148289. View

16.

McQuibban G, Gong J, Wong J, Wallace J, Clark-Lewis I, Overall C . Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo. Blood. 2002; 100(4):1160-7. View

17.

Bixel M, Li H, Petri B, Khandoga A, Khandoga A, Zarbock A . CD99 and CD99L2 act at the same site as, but independently of, PECAM-1 during leukocyte diapedesis. Blood. 2010; 116(7):1172-84. DOI: 10.1182/blood-2009-12-256388. View

18.

Bixel M, Petri B, Khandoga A, Khandoga A, Wolburg-Buchholz K, Wolburg H . A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo. Blood. 2007; 109(12):5327-36. DOI: 10.1182/blood-2006-08-043109. View

19.

Sabeh F, Li X, Saunders T, Rowe R, Weiss S . Secreted versus membrane-anchored collagenases: relative roles in fibroblast-dependent collagenolysis and invasion. J Biol Chem. 2009; 284(34):23001-11. PMC: 2755707. DOI: 10.1074/jbc.M109.002808. View

20.

Furie M, Naprstek B, Silverstein S . Migration of neutrophils across monolayers of cultured microvascular endothelial cells. An in vitro model of leucocyte extravasation. J Cell Sci. 1987; 88 ( Pt 2):161-75. DOI: 10.1242/jcs.88.2.161. View